Page 315 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 16 ■ Hemolytic Anemias 299

M m m , m . C

m m m . MCV, MCH, MCHC, m m

m m . m m . I m z m

, x k , - -
Spur Cell Hem olytic Anem ia m , PK, m

T m - m m m m . M z m

. A m m m m

m x m % m .

% . H m m

m m . I m ,

m / L. Glucose-6-Phosphate Dehydrogenase

R % %, Glucose-6-phosphate dehydrogenase (G6PD de ciency),

C - - m m mm z m ,

. M mm . x ,

O - , , . D

, k , M L , m q m

m ( . ., x ). x m % Am B k m ,

m , q , q
Neuroacanthocytosis m m

N (NA) -B k .

- T X- k z m , G PD ,

. C , NA z m . S m M E

m . T x m G PD ,

k , x m , % m K J % m

m m , m j B .

m m . M z m -

NA x m . , m

m m . R. I z G PD- I m .

. R . A M , m m ,

m

G PD . G PD m
NOTE: This is a good time to review the de nitions of Key m . F x m z -

Terms found in the Glossary and ash cards on . It m . I m , x

is also a good time to complete the Review Questions related m . I m

to the preceding content. m ( z ), -

x . O

m z m ;
Erythrocytic Enzym e Metabolism Defects G PD .

L k m m , z m T , k , m-

m m . D - z m . T

m m m x m

m m (CNSHA). CNSHA q m . T z m

G PD z :

m m, -

+
+
z m , , - Glucose-6-phosphate NADP G6PD → 6-phosphogluconate NADPH
m m. H m z m

x , T -

, ( - ). N m - -

. (NADPH)

T m m . A x m -

, x z , m
. G - - (G PD) NADPH m

. P k (PK) m x m .
. M m
L q -

T z m . G PD, m

S m m m m , , H z

m m H z . H z