Page 370 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

Principles of Blood Collection and
19 Disorders of Lymphocytes

CHAPTER Processing

KEY TERMS

acquired im m unode ciency infectious m ononucleosis lym phoproliferative

syndrom e leukopenia reactive lym phocytosis
cytom egalovirus lym phocytopenia seronegativity

Epstein-Barr virus lym phocytosis system ic lupus erythem atosus

LEARNING OUTCOMES

Characteristics of lymphocytes Describe the etiology, epidemiology, clinical signs and symptoms,

■ State the normal relative value reference range for lymphocytes in and laboratory data for Bordetella pertussis (whopping cough).
an adult. Describe the etiology, epidemiology, clinical signs and symptoms,

■ State the absolute number of lymphocytes using the total leukocyte and laboratory data for reactive lymphocytosis.
count and the relative number of lymphocytes. Lymphocytopenia

■ Explain the difference between an absolute lymphocyte count and a De ne and explain the term lymphocytopenia.
relative lymphocyte count. ■

■ Name several disorders of lymphocytes frequently encountered in Explain the pathophysiology and laboratory features in transient
the hematology laboratory. lymphocytopenia and pathological lymphocytopenia and congenital
qualitative disorders of lymphocytes.

Lymphocytosis Immune disorders associated w ith

■ Describe why lymphocytosis occurs in infants and children up to lymphocytopenia

10 years of age.

■ Name at least three nonmalignant conditions associated with an ■ Name major immune de ciencies associated with T cells or B cells.

absolute lymphocytosis. Describe the pathophysiology of early-phase and late-phase

■ Name at least three malignant conditions associated with lymphocytosis. acquired immunode ciency syndrome (HIV/AIDS).
Assess the hematology laboratory patient data, including serologi-

Disorders associated w ith lymphocytosis cal markers in HIV/AIDS.

■ Describe the etiology, epidemiology, clinical signs and symptoms, Describe the etiology, epidemiology, clinical signs and symptoms,

and laboratory data for infectious mononucleosis. and laboratory ndings of systemic lupus erythematosus.

■ Describe and recognize the appearance of lymphocytes associated Case studies

with infectious mononucleosis.

Correlate the heterophil antibody test to a diagnosis of infectious Analyze the patient history, clinical signs and symptoms, and labo-

mononucleosis. ratory data for the stated case studies, answer the related critical

Assess and correlate traditional antibody titers found in infectious thinking questions, and conclude the most likely diagnosis.

mononucleosis with EBV viral antigens.

Describe the etiology, epidemiology, clinical signs and symptoms, NOTE:

and laboratory data for cytomegalovirus. ■ indicates MLT and MLS core content

Describe the etiology, epidemiology, clinical signs and symptoms, indicates MLT (optional) and MLS advanced content

and laboratory data for toxoplasmosis.

CHARAC ERIS ICS OF LYMPHOCY ES . . × /L. A
m lymphocytopenia. W

T m m m m
% %. T m , lymphocytosis.

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