Page 375 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 19 ■ Disorders of Lymphocytes 359

Acute FIGURE 19.4 A -

Incubation illness Convalescence EBV. (VCA, ; HA,
; EA, ; EBNA,
IgG VCA
EBV .) (S : H W, H

IgG EA G. S m . I : E M,

A B ( .). Te Epstein-Barr Virus. B ,
r EBNA
e G m : S -V , : – ;
t
Ti HA mk B, S J. E -B -

IgM VCA m . I : G S, B J,
B k N ( .). In ectious Diseases, P ,
PA: WB S , : – .)

0 1 2 3 4 5 6 7

Months

m % Cytomegalovirus Infection

m

. Etiology

F T -

m , m m mm CMV

m EBV . . I , CMV

C EBV . I ,

x m m , - .

, mm . H m CMV m m m-

EBV- B m x . T z m

(F . . ). I : m x I, m x II, -

EBV x (VCA), z , EBV, CMV. A -

(EA), (NA), - , DNA

. A mm DNA x m

M (I M) G (I G) EBV . T

. EBV- ( . ) m m

mm , m - .

m A m -

(F . . ). T m m ,

m m EBV- . T q m ,

. m m , m

A -I

m . T m x . T mm m

m . -

m .

Epidem iology
NOTE: This is a good time to review the de nitions of Key Terms

in the Glossary and ash cards for . Also, a good time CMV q m m

to complete Review Questions related to preceding content. . m CMV q -
m x ( m ,

TABLE 19.4 Characteristic Antibody Formation in Infectious Mononucleosis

VCA IgM VCA IgG EA-D EA-R EBNA IgG Heterophil

No previous exposure − − − − − −

Recent (acute) infection + + ± − − +

Past infection (convalescent) period − + − − + −

Reactivation of latent infection ± + + ± + ±

VCA, viral capsid antigen; EA-D, early antigen (diffuse); EA-R, early antigen (restricted); EBNA, Epstein-Barr nuclear antigen; IgG, immunoglobulin G.