Page 371 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 19 ■ Disorders of Lymphocytes 355

TABLE 19.1 Examples of Nonmalignant Disorders of Lymphocytes

Disorder Etiology Laboratory Data

Viral disorders

Infectious mononucleosis EBV Lymphocytosis

Variant lymphocytes
Increased titer of heterophil antibodies

Reactive lymphocytosis Coxsackie group Lymphocytosis

Negative for heterophil antibodies

CMV infection Herpes group—CMV Slight lymphocytosis
Variant lymphocytes

Negative for heterophil antibodies
Positive for ANA, RA, and CMV nonspeci c antibodies

AIDS HIV Leukopenia

Lymphocytopenia

Abnormality of T-cell subsets

Bacterial disorders

Whooping cough Bordetella pertussis Signi cant lymphocytosis

Rare lymphoblasts

All antibodies negative

Parasitic disorders

Toxoplasmosis Toxoplasma gondii Variant lymphocytes

Negative for heterophil antibodies

Positive for Toxoplasma antibodies

Autoimmune disorders

Systemic lupus Autoimmune Positive LE cell preparation

erythematosus Positive for ANA antibodies

Lymphocyte subset abnormalities

ANA, antinuclear antibodies; RA, rheumatoid factor antibodies; CMV cytomegalovirus; AIDS, acquired immunode ciency syndrome; HIV human immunode -
,
,
ciency virus.

D m ( . ) q m m

. M - m . T m

m m . m m m

Ex m infectious mononucleosis, m

cytomegalovirus (CMV) , q mm - .

m (AIDS). B L m mm

m . T - mm . I -

x m , , m

, m m . m

I , - ( mm - . A ( . ., m ,

) m , m , CMV
m m , reactive lymphocytosis)

m ( . ).
. S m ( . ., Bordetella pertussis -

[ ] )

LYMPHOCY OSIS . P ( . ., x m )

. D ( . ., p- m -

Lymphocytosis m - )

x m , m - . U mm ( . .,

× /L. T m x)