Page 505 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

PA RT S EV EN

Principles and Disorders of

Hemostasis and T rombosis

25 Principles of Hemostasis and

Principles of Blood Collection
CHAPTER Trombosis: Vasculature and Platelets

KEY TERMS

aggregate endothelium platelet adhesion
alpha granules extrinsic system platelet aggregation

delta granules glycocalyx platelet plug
dense granules intrinsic system system ic circulation

endoreduplication lysosom es throm bocytopenia
endothelial dysfunction m egakaryocyte throm bocytosis

endothelins mononuclear phagocytic system vasoconstriction

LEARNING OUTCOMES

Overview of hemostasis and thrombosis ■ Describe the process of formation of platelets from a

■ Describe the components of bleeding and clotting mechanisms. megakaryocyte.
■ List the ultrastructural components and cytoplasmic constitu-
Blood vasculature: structure and function ents of a mature platelet and describe the overall function of

■ Describe and compare the histological features of the tissues of the each.
arteries and veins. ■ Explain the life span activities of a mature platelet.

■ Name the blood vessels that constitute the microcirculation and ■ Explain the function of platelets in response to vascular damage.
compare their size and other features with those of arteries and ■ Define generally the terms platelet adhesion and platelet

veins. aggregation.

■ De ne the term vasoconstriction. ■ Explain the events that take place during platelet adhesion, includ-

■ Explain how vasoconstriction participates in hemostasis. ing the substances produced.

■ Describe the metabolic activity of the endothelium and its role in ■ Explain the events that take place during platelet aggregation.
hemostasis. ■ List substances that promote and substances that inhibit some

■ Outline the general process of hemostasis in small vessels that aspects of platelet aggregation.
contributes to the maintenance of vascular integrity. ■ Brie y describe the process of platelet plug consolidation and

stabilization.
The megakaryocytic cell series

■ De ne the term endoreduplication and relate this process to

megakaryocytic development. NOTE:

■ List and explain the three functions of thrombopoietin or ■ Indicates MLT and MLS core content

thrombopoietin-like cytokines. Indicates MLT (optional) and MLS advanced content

■ Describe the morphological features of the mature stages of devel-

opment in the megakaryocyte series.

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