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644            PART 8  ■  Fundamentals of Hematological Analysis







                             CASE STUDIES (continued)
                               CASE STUDIES (continued)




                  Her WBC histogram appears below. T e platelet count was                                                                   23

                  decreased. All erythrocytic parameters were within normal

                  ranges; however, the values tended to be in the low ends o

                  the ranges.

                                                                                                                                            21





                                                                                                                                                    25
                                                                                                                                            19
                                                                                                                                     fL






                                                                                                                                                                                             29
                                                                                                                                            17
                  ■   Questions                                                                                                             15                             27   1
                  1.  Do the histogram or other leukocyte results demon-                                                                       13   9   11                7

                       strate any abnormalities?

                  2.  What type o  disorder, i  any, is suggested by the WBC

                       results and histogram?

                  3.  What  urther laboratory testing should be considered?                                                                              0.2              0.3              0.4


                                                                                                                                                                                          12
                                                                                                                                                               Platelet count (x 10 /L)
                     Case Study 30.5

                                                                                                                           ■    Critical Thinking Group Discussion Questions
                  ■   Laboratory Data                                                                                      1.  Did the patient have an initial abnormality?
                  A 12-year-old black boy had a total leukocyte count o

                  55.0 × 10 /L. His histogram appears below.                                                               2.  Did the patient develop any abnormalities  ollowing
                                 9
                  His  platelet  count  was  low,  as  were  his  erythrocyte                                                    treatment?

                   parameters.  Additionally,  his  platelet  histogram  was

                  abnormal.                                                                                                3.  Did the patient’s values return to normal?



                                                                                                                               Case Study 30.7



                                                                                                                           ■    History and Physical

                                                                                                                           M.W., a 50-year-old male clinical laboratory scientist, saw
                                                                                                                           his primary care provider  or an examination prior to a


                                                                                                                           6-month international volunteer assignment. He  elt well
                                                                                                                           and had no symptoms o  any abnormalities.


                                                                                                                           A urinalysis and CBC were ordered.


                  ■   Critical Thinking Group Discussion Questions                                                         ■    Laboratory Data

                  1.  Do the histogram or other leukocyte results demon-                                                   Urinalysis: All results within re erence ranges.

                       strate any abnormalities?
                                                                                                                           ■    Hematology Laboratory


                  2.  What type o  disorder, i  any, is suggested by the WBC                                                  Measurement                     Patient Data                 Reference Range*

                       results and histogram?

                                                                                                                              RBC                             5.03 × 10 /µL                4.00–6.20
                                                                                                                                                                          6
                  3.  What  urther laboratory testing should be considered?                                                   Hgb                             15.2 g/dL                    11.0–18.8


                                                                                                                              Hct                             45%                          35.0–55.0
                     Case Study 30.6
                                                                                                                              WBC                             5.1 × 10 /µL                 6.0–11.0
                                                                                                                                                                        3
                  ■   Laboratory Data                                                                                         PLT                             175 × 10 /µL                 150.0–400.0
                                                                                                                                                                         3
                    A 28-year-old white woman underwent a chemothera-                                                         MCV                             89 fL                        80.0–100.0

                    peutic regimen  or the treatment o  leukemia. Her ini-

                    tial platelet count and MPV as well as successive platelet                                                MCH                             30 pg                        26.0–34.0

                    counts and MPVs, beginning on the 7th day a  er the ter-                                                  MCHC                            34 g/dL                      31.0–35.0

                    mination o  treatment, were assayed every other day and                                                   RDW                             18%                          10.0–20.0

                    charted by the laboratory.                                                                                MPV                             9.1 fL                       6.0–10.0



                                                                                                                               fL, femtoliters; pg, pictogram.

                                                                                                                               * Published for Beckman Coulter A  T .
                                                                                                                                                                           C TM
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