Page 388 - Review of Medical Microbiology and Immunology ( PDFDrive )
P. 388
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CHAPTER 44 Slow Viruses & Prions
4. Regarding prion-mediated diseases, which one of the following is
the most accurate?
Brief summaries of the organisms described in this chapter
(A) Prion-mediated diseases are characterized by vacuoles in the
begin on page 677. Please consult these summaries for a rapid
brain called “spongiform changes.”
(B) Variant Creutzfeldt-Jakob disease is a disease of cattle caused
review of the essential material.
by the ingestion of sheep brain mixed into cattle feed.
(C) Kuru is a prion-mediated disease for which the diagnosis can
be confirmed in the laboratory by a fourfold or greater rise in
antibody titer.
COURSE EXAMINATIONS
(D) In Creutzfeldt-Jakob disease, only neurons latently infected by PRACTICE QUESTIONS: USMLE &
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Questions on the topics discussed in this chapter can be found
JC virus produce the prion filaments that disrupt neuronal
function.
in the Clinical Virology section of Part XIII: USMLE (National
(E) Creutzfeldt-Jakob disease occurs primarily in children under
Board) Practice Questions starting on page 723. Also see Part
the age of 2 years because they cannot mount an adequate
immune response to the prion protein.
on page 751.
ANSWERS
1. (B)
2. (B)
3. (C)
4. (A)
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