Page 388 - Review of Medical Microbiology and Immunology ( PDFDrive )
P. 388

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 mebooksfree.com  mebooksfree.com           mebooksfree.com              SUMMARIES OF ORGANISMS                         377                mebooksfree.com
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                                                                                       CHAPTER 44  Slow Viruses & Prions
                    4.  Regarding prion-mediated diseases, which one of the following is
                      the most accurate?
                                                                         Brief summaries of the organisms described in this chapter
                      (A)  Prion-mediated diseases are characterized by vacuoles in the
                                                                         begin on page 677. Please consult these summaries for a rapid
                          brain called “spongiform changes.”
                      (B)  Variant Creutzfeldt-Jakob disease is a disease of cattle caused
                                                                         review of the essential material.
                          by the ingestion of sheep brain mixed into cattle feed.
                      (C)  Kuru is a prion-mediated disease for which the diagnosis can
                          be confirmed in the laboratory by a fourfold or greater rise in
                          antibody titer.
                                                                         COURSE EXAMINATIONS
                      (D)  In Creutzfeldt-Jakob disease, only neurons latently infected by   PRACTICE QUESTIONS: USMLE &
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 mebooksfree.com  mebooksfree.com           mebooksfree.com              XIV: USMLE (National Board) Practice Examination starting         mebooksfree.com
                                                                         Questions on the topics discussed in this chapter can be found
                          JC  virus produce  the  prion  filaments  that  disrupt  neuronal
                          function.
                                                                         in the Clinical Virology section of Part XIII: USMLE (National
                      (E)  Creutzfeldt-Jakob disease occurs primarily in children under
                                                                         Board) Practice Questions starting on page 723. Also see Part
                          the age of 2 years because they cannot mount an adequate
                          immune response to the prion protein.
                                                                         on page 751.
                    ANSWERS
                    1.  (B)
                    2.  (B)
                    3.  (C)
                    4.  (A)
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