Page 556 - Review of Medical Microbiology and Immunology ( PDFDrive )

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mebooksfree.com mebooksfree.com mebooksfree.com 5. A deficiency of which one of the following complement compo- mebooksfree.com
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CHAPTER 63 Complement
545
SELF-ASSESSMENT QUESTIONS
nents predisposes to bacteremia caused by members of the genus
1. Regarding the complement pathway, which one of the following is
Neisseria?
the most accurate?
(A) C1
(A) C3 convertase protects normal cells from lysis by complement.
(B) C3b
(B) C3a is a decay-accelerating factor and causes the rapid decay
(C) C5a
and death of bacteria.
(D) C5b
(C) In general, gram-positive bacteria are more likely to be killed
(E) C5b,6,7,8,9
by complement than gram-negative bacteria.
(D) The membrane attack complex is formed as a result of activa- 6. Your patient is a 20-year-old woman who complains of swellings
on her arms and legs and a feeling of fullness in her throat that
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tion of the classic pathway but not by activation of the alterna-
makes it difficult to breath. The swellings are not red, hot, or ten-
tive pathway.
der. You suspect she may have angioedema caused by a comple-
(E) The first time a person is exposed to a microorganism, the
ment abnormality. Of the following, which one is the most likely
alternative pathway of complement is more likely to be acti-
explanation?
vated than the classic pathway.
(A) She has too little C1 inhibitor.
2. Of the following complement components, which one is the most
(B) She has too little C3b.
important opsonin?
(C) She has too little factor B.
(A) C1
(D) She has too much C5a.
(B) C3a
(E) She has too much C9.
(C) C3b
(D) C5a
(E) C5b
3. Of the following complement components, which one is the most
potent in attracting neutrophils to the site of infection (i.e., acting ANSWERS
2. (C)
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as a chemokine)?
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3. (D)
4. (D)
(A) C1
5. (E)
(B) C2
(C) C3b
(D) C5a
(E) Mannan-binding lectin
PRACTICE QUESTIONS: USMLE &
4. Of the following, which one is the most important function of the
COURSE EXAMINATIONS
complex formed by complement components C5b,6,7,8,9?
(A) To enhance antibody production
Questions on the topics discussed in this chapter can be
(B) To inhibit immune complex formation
found in the Immunology section of Part XIII: USMLE
(C) To opsonize viruses
(National Board) Practice Questions starting on page 733.
(D) To perforate bacterial cell membranes
(E) To release histamine from mast cells
Also see Part XIV: USMLE (National Board) Practice Exami-
nation starting on page 751.
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