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70                                  HUFFMAN ET. AL



      in MRI may have future potential in gaining a better   REFERENCES
      understanding of the perivascular flow in humans.   1.  Abbott, N. Evidence for bulk flow of brain inter-
      Successful visualization of CSF and ISF flow in clin-  stitial fluid: significance for physiology and
      ically relevant brain regions may help uncover the   pathology. Neurochem. Int. 45:545-552; 2004.
      neuropathology of AD and related disorders.   2.  Abdullah, A.; Hirayama, A.; Yatsushiro, S.;
                                                       Matsumae, M.; Kuroda, K. Cerebrospinal fluid
      SUMMARY                                           pulsatile segmentation - a review. In 5th Biomed.
        CSF-ISF movement throughout the brain is a cen-  Engin. Int. Conf. Ubon Ratchathani, Thailand:
      tral mechanism to the removal of metabolic waste   2012.
      associated with the pathology of neurodegenerative   3.  Akbar, J.J.; Luetmer, P.H.; Schwartz, K.M.; Hunt,
      disorders. Clearing the interstitial space is driven by   C.H.; Diehn, F.E.; Eckel, L.J. The role of MR
      either the bulk flow of ISF along periarterial pathways   myelography with intrathecal gadolinium in
      (53) or the glymphatic flow of subarachnoid CSF into   localization of spinal CSF leaks in patients with
      the parenchyma and subsequent CSF-ISF exchange    spontaneous intracranial hypotension. Am. J.
      (36). Fluid cleared from the interstitium then interacts   Neuroradiol. 33:535-540; 2012.
      with CSF absorption pathways (57) or drains along   4.  Arbel-Ornath, M.; Hudry, E.; Eikermann-Haerter,
      the meningeal lymphatic vessels (5,50). While these   K.; Hou, S.; Gregory, J.; Zhao, L.; Betensky, R.;
      clearance routes shed light on a possible means of   Frosch, M.; Greenber S.; Bacskai, B. Interstitial
      removing proteins such as Aβ, current technology is   fluid drainage is impaired in ischemic stroke
       limited in its ability to image the movement of CSF   and Alzheimer’s disease mouse models. Acta.
      and ISF along perivascular pathways while maintain-  Neuropathol. 126:353-364; 2013
      ing clinical significance.                    5.  Aspelund, A.; Antila, S.; Proulx, S.; Karlsen, T.;
        Whereas advanced imaging in animal models,     Karaman, S.; Detmar, M.; Wiig, H.; Alitalo, K.
       such as two-photon microscopy, has produced     A dural lymphatic vascular system that drains
      insights into the structural and functional char-  brain interstitial fluid and macromolecules. J.
      acteristics of fluid movement, human studies are   Exp. Med. 212:991-999; 2015.
      needed to similarly characterize these dynamics.   6.  Aydin, K.; Terzibasioglu, E.; Sencer, S.; Sencer,
      Numerous clinical studies have utilized MRI to   A.; Suoglu, Y.; Karasu, A.; Kiris, T.; Turantan,
      examine dilated perivascular spaces, which may be   M.I. Localization of cerebrospinal fluid leaks
      a marker of impaired fluid movement in the perivas-  by gadolinium-enhanced magnetic resonance
      cular system (12,15,22,30,53,56). While these spaces   cisternography: a 5-year single center experience.
      are implicated in a number of neurological disorders,   Neurosurgery 62:584-589; 2008.
      imaging preexisting dilations does not permit insight   7.  Battal, B.; Kocaoglu, M.; Bulakbasi, N.; Husmen,
      into the underlying mechanisms. The potential for   G.; Sanal, H.; Tayfun, C. Cerebrospinal fluid flow
      CSF flow dynamics to influence onset or progression   imaging by using phase-contrast MR technique.
      of neuropathological disorders raises the importance   Brit. J. Radiol. 84:758-765; 2011.
      of needed technical advances to examine these pro-  8.  Bedussi, B.; G. J. T. B. van Lier, M.; Bartstra,
      cesses. Gadolinium-based contrast materials for MRI   J.; Vos, J.; Siebes, M.; Vanbavel, E.; Bakker, E.
      have potential for validating perivascular activity in   Clearance from the mouse brain by convection
      humans and fluctuations in fluid movement that may   of interstitial fluid towards the ventricular system.
       lead to the onset and progression of neurodegenera-  Fluids Barriers CNS 12:1-13; 2015.
      tive diseases.                                9.  Cai, K.; Tain, R.; Das, S.; Damen, F.C.; Sui, Y.;
                                                       Valyi-Nagy, T.; Elliot, M.A.; Zhou, X.J. The feasi-
      ACKNOWLEDGMENTS                                   bility of quantitative MRI of perivascular spaces
      The authors declare no conflict of interest.      at 7T. J. Neurosci. Meth. 256:151-156; 2015.
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