Page 37 - Drug Discovery and Development: Prospects and Challenges

(Mokhtari et al., 2017). The two most significant approval of the combination of drug nanocarrier
includes Vyxeos™ and chimeric antigen receptor T cells (CAR-T) therapy, Kymriah™ and or
Yescarta™ (Ghosh et al., 2019).
The b-mangostin is an active compound from G. mangostana with low solubility due to its
hydrophobic property. Based on our preliminary study, b-mangostin in its original form (non-
formulated) showed strong activity against Caco-2 cells (IC50= 8.27 µg/mL). It is expected that the
activity against multidrug-resistant cancer cells would be enhanced by improving its formulation. The
study was also designed to incorporate b-mangostin to a PEGylated liposome loaded (Figure 22) with
doxorubicin to overcome multidrug-resistant of colon cancer cells to provide a synergistic effect
(Taher, 2021, unpublished).
Drug Discovery and Development: Prospects and Challenges / 27

Figure 22: PEGylated liposome formulation with b-mangostin to improve
Figure 22: PEGylated liposome formulation with b-mangostin to improve delivery in colon cancer
delivery in colon cancer cells
cells

Brothers and sisters,
Ladies and Gentlemen,
Brothers and sisters,
Ladies and Gentlemen,
The Miracle Plant, Centella asiatica

THE MIRACLE PLANT, Centella asiatica
Introduction of C. asiatica

C. asiatica (L.) is an Asian native wetland medicinal herb commonly
Introduction of C. asiatica
known as pegaga, pegagan, daun kaki kuda, gotu kola, or Asian
C. asiatica (L.) is an Asian native wetland medicinal herb commonly known as pegaga,
pennywort. Besides its role as a medicinal plant for thousands of years,
pegagan, daun kaki kuda, gotu kola, or Asian pennywort. Besides its role as a medicinal plant for
particularly in the Ayurvedic system in India and as a traditional folk
medicine in China and Madagascar, C. asiatica has caught our attention
thousands of years, particularly in the Ayurvedic system in India and as a traditional folk medicine in
to study its unique properties. The herb possesses active principles
comprising triterpenoids, such as asiaticoside, madecassoside, and
asiatic acid (Figure 23). The huge attention on this plant is related to its 32
activity on skin generation, boosting memory, increasing concentration
and alertness, and anti-stress. During the wound healing process, C.
asiatica stimulates collagen synthesis, which allows the skin to proliferate
effectively.