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Inherited disorders



            Inherited, or genetic, disorders are problems passed on from one
            generation to the next. There are certain disorders associated with
            particular breeds; a few major genetic disorders are covered here.

            Why do inherited                filled cysts form in the kidneys   Hypokalemic
            disorders occur?                and gradually increase in size.    polymyopathy
            Inherited disorders result from   The disease causes increased urine   This disorder is associated with
            faults in genes—sections of     production, excessive thirst, weight   Burmese, related breeds such as
            DNA inside cells, which hold    loss, and lethargy. Screening for   the Bombay and Tonkinese, and
            the “instructions” for the cat’s   PKD is possible through DNA   Rex cats. An autosomal recessive
            development, body structures,    analysis of cheek swabs.      disorder, it is caused by faulty genes
            and functions. Genetic disorders                               from both parents. In hypokalemic
            usually develop in small        HCM                            polymyopathy, low potassium levels
            populations, or result from the   Hypertrophic cardiomyopathy   in the blood cause episodes of weak
     46     mating of animals that are too   (HCM) is mainly associated with   muscles, a stiff walk, and reduced
            closely related. For this reason,   the Maine Coon and Ragdoll, and    ability to hold up the head. The cat
            such disorders are more common   is linked to one faulty gene. The   may have difficulty breathing and
                                            disorder causes the heart muscle
                                                                           standing. There is a gene test for
            in pedigrees. Sometimes screening
      Your cat’s health  with inherited disorders.  which reduces the space inside the   potassium supplements.
            tests can be used to identify cats
                                            to become thicker and less elastic,
                                                                           the disorder; it can be treated with
                                            heart’s chambers and the volume
            PKD
                                            of blood that the heart can pump.
                                            This eventually leads to heart
            Polycystic kidney disease (PKD) is
            associated with Persian and Exotic
                                            breathlessness, lethargy, and loss
            Shorthair cats. It is an autosomal   failure. Symptoms of HCM include
            dominant disorder—that is, a cat   of appetite. Screening involves
            can inherit it from just one parent.   gene tests and ultrasound scans
            In PKD, a large number of fluid-   of the heart.











                                                                           △  Burmese cat
                                                                           Hypokalemic polymyopathy may first appear at
                                                                           2–6 months, often in Burmese or related Asian
                                                                           breeds. Episodes can be brought on by stress,
                                                                           cold weather, or exercise.


                                                                           ◁  PKD and Persian cats
                                                                           Persians are one breed at risk of polycystic
                                                                           kidney disease. In this disorder, fluid-filled cysts
                                                                           develop in the kidneys, enlarging throughout the
                                                                           cat’s life and leading to kidney failure.





   US_046-047_Inherited_musculo_disorders.indd   46                                                  24/10/2013   14:56
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