Page 249 - First Aid for the USMLE Step 1 2020, Thirtieth edition [MedicalBooksVN.com]_Neat

HIGH-YIELD PRINCIPLES IN

SEC TION II Pathology

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“Digressions, objections, delight in mockery, carefree mistrust are signs of `Cellular Injury 206
health; everything unconditional belongs in pathology.”
—Friedrich Nietzsche `Inflammation 213

“You cannot separate passion from pathology any more than you can `Neoplasia 219
separate a person’s spirit from his body.”
—Richard Selzer

The fundamental principles of pathology are key to understanding
diseases in all organ systems. Major topics such as inflammation and
neoplasia appear frequently in questions across different organ systems,
and such topics are definitely high yield. For example, the concepts of
cell injury and inflammation are key to understanding the inflammatory
response that follows myocardial infarction, a very common subject of
board questions. Similarly, a familiarity with the early cellular changes
that culminate in the development of neoplasias—for example,
esophageal or colon cancer—is critical. Finally, make sure you
recognize the major tumor-associated genes and are comfortable with
key cancer concepts such as tumor staging and metastasis.

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