Page 459 - First Aid for the USMLE Step 1 2020, Thirtieth edition [MedicalBooksVN.com]_Neat

Hematology and oncology ` hematology and oncology—Pathology Hematology and oncology ` hematology and oncology—Pathology SectIon III 415

RBC morphology (continued)
tyPe eXamPle aSSocIated Pathology noteS
Spherocytes Hereditary spherocytosis, Small, spherical cells without
autoimmune hemolytic anemia central pallor

Macro-ovalocytes Megaloblastic anemia (also
hypersegmented PMNs)

Target cells HbC disease, Asplenia, “HALT,” said the hunter to his
Liver disease, Thalassemia target

Sickle cells Sickle cell anemia Sickling occurs with low O
2
conditions (eg, high altitude,
acidosis)

FAS1_2019_10-HemaOncol.indd 415 11/7/19 5:04 PM