Page 460 - First Aid for the USMLE Step 1 2020, Thirtieth edition [MedicalBooksVN.com]_Neat

416 SectIon III Hematology and oncology ` hematology and oncology—Pathology Hematology and oncology ` hematology and oncology—Pathology

RBC inclusions
Bone marrow
tyPe eXamPle aSSocIated Pathology noteS
Iron granules Sideroblastic anemias (eg, lead Perinuclear mitochondria with
(eg, in ringed poisoning, myelodysplastic excess iron (forming ring in
sideroblasts) syndromes, alcoholism) ringed sideroblasts)
Require Prussian blue stain to be
visualized

Peripheral smear
Howell-Jolly bodies Functional hyposplenia (eg, sickle Basophilic nuclear remnants (do
cell disease), asplenia not contain iron)
Usually removed by splenic
macrophages

Basophilic stippling Sideroblastic anemias, thalassemias Basophilic ribosomal precipitates
(do not contain iron)

Pappenheimer bodies Sideroblastic anemia Basophilic granules (contain iron)

Heinz bodies G6PD deficiency Denatured and precipitated
hemoglobin (contain iron)
Phagocytic removal of Heinz
bodies Ž bite cells
Requires supravital stain (eg,
crystal violet) to be visualized

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