Page 589 - First Aid for the USMLE Step 1 2020, Thirtieth edition [MedicalBooksVN.com]_Neat

Neurology aNd Special SeNSeS ` neurology—PhArmACology Neurology aNd Special SeNSeS ` neurology—PhArmACology SecTioN iii 545

Epilepsy therapy (continued)

EXCITATORY
NEURON
Action
Na CHANNEL BLOCKERS potential
+
+
Ca² CHANNEL BLOCKERS

Carbamazepine Voltage-gated
+
Fosphenytoin Na channel Ethosuximide
Lamotrigine Na + Gabapentin
Phenytoin
Topiramate Depolarization
Valproic acid Voltage-gated
2+
Ca channel
Glutamate vesicle Ca
2+
release
SV2A RECEPTOR BLOCKER SV2A
receptor
Levetiracetam
Ca
2+
Na +
NMDA
receptor
AMPA
GABA A AGONISTS receptor
Depolarization
Benzodiazepines
Topiramate GABA A Cl _
Phenobarbital receptor
Propofol
Action
Cl _ potential

GABA GABA POST-SYNAPTIC
reuptake NEURON
GAD receptor GABA REUPTAKE
Glutamate INHIBITOR
GABA
Succinic semi-
INHIBITORY GABA Tiagabine
NEURON aldehyde (SSA) transaminase
GABA TRANSAMINASE
INHIBITORS

Valproic acid
Vigabatrin

FAS1_2019_12-Neurol.indd 545 11/8/19 7:39 AM