Page 651 - First Aid for the USMLE Step 1 2020, Thirtieth edition [MedicalBooksVN.com]_Neat
P. 651
Renal ` RENAL—PAthoLogy Renal ` RENAL—PhARmACoLogy SeCTIOn III 607
` RENAL—PhARmACoLogy
Diuretics site of action
Distal
HCO – 3 convoluted
Glomerulus Na + 4 tubule Ca 2+
Proximal Na – +
A erent 2 convoluted CI
tubule
E erent
1
Sugars K + 5
Amino acids
H O H +
2 Na +
5
Ca 2+ Na +
Mg 2+
Cortex
Medulla 3
Na +
K +
2CI –
1 Mannitol
Descending limb,
2 Acetazolamide loop of Henle Ascending limb,
(permeable to water) loop of Henle
3 Loop diuretics (permeable to salts)
4 Thiazide diuretics
5 K sparing diuretics
+
Collecting
duct
Loop of Henle
Mannitol
mEChANism Osmotic diuretic. tubular fluid osmolarity urine flow, intracranial/intraocular pressure.
CLiNiCAL UsE Drug overdose, elevated intracranial/intraocular pressure.
ADVERsE EFFECts Pulmonary edema, dehydration, hypo- or hypernatremia. Contraindicated in anuria, HF.
FAS1_2019_14-Renal.indd 607 11/7/19 5:42 PM
