Page 102 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

A. Regulation of RBC production B. Life cycle of red blood cells
1 Hypoxia Bone marrow

PO 2 High altitude, etc.
RBC formation
PO 2
Kidney Life span:
120 days
Erythrocytes
Erythropoietin
Blood Composition and Function of Blood

Bone marrow
2 Hemolysis
Break-
Hemolysis down
PO 2
Spleen “Still good”
Test
PO 2
“Too old” Plate 4.1
Spenic
Phagocytosis pulp
by
Erythropoietin macrophages in: Pulpal
arteriole
Bone marrow
Lymph nodes Sinus
Spleen
Liver, etc.
C. Erythrocyte parameters MCH, MCV and MCHC
Centrifugation
Blood sample
a MCH (mean Hb mass/RBC)
b Hb conc.
= (g/RBC)
red cell count Normal:
27–32pg
Hematocrit (Hct)=b/a
(L RBC /L Blood )
MCV (mean volume of one RBC)
Hct
Hemoglobin concentration = (L/RBC)
(g/L BLOOD ) red cell count Normal:
Red cell count (RCC) 80–100fl
(quantity/LBLOOD)
MCHC (mean Hb conc. in RBCs)
Hb conc.
= (g/L RBC )
Hct Normal:
320–360g/L
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Despopoulos, Color Atlas of Physiology © 2003 Thieme
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