Page 110 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

B. Specific immunity: T-cell activation
T lymphocytes +
+
CD4 T cells recognize
CD8 T cells recognize
Antigen-presenting cells: antigen in HLA(MHC)-I antigen in HLA(MHC)-II
– Macrophages
– Dendritic cells
– B cells
APC Antigen T cell
HLA-I CD8 or CD4 “Naive”
or HLA-II T-cell receptor T cell
Dual signal
B7 CD28 Immune System II
Example: 1
Dendritic cell ICAM LFA1
IL-2
Plate 4.5
IL-2 receptor

T-cell proliferation
(clonal expansion and differentiation)
CD8/HLA-I CD4/HLA-II

Infected cell, T H2 cell
tumor cell, foreign cell
Cytotoxic T cell T H1 cell
IL-10,
TGFβ
IFNγ

See plate C
Infected T cell
cell ICAM LFA1
HLAI CD8
T-cell receptor Macrophage
activation
Antigen
CD95 Fas ligand 3
Apoptosis Perforins
Granzyme B
2 Macrophage
97
Inflammation
Despopoulos, Color Atlas of Physiology © 2003 Thieme
All rights reserved. Usage subject to terms and conditions of license.