Page 108 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

A. Nonspecific immune defenses enhanced by specific antibodies
Humoral Cellular
Lysozyme Fc and C3b
receptors
Damages membranes
Interferons (IFN)
IFN-α, β, γ inhibit Neutrophils,
viral proliferation; Monocytes Antigen Ig
IFN-γ activates macrophages, → Macrophages 2 C3b
killer cells,
B and T cells Antigens opsonized
Phagocytosis by Ig and C3b
Complement activation
1 Immune System I
Alternative Classical
C3 C1q Lysis
Release of:
Antigen-antibody Oxidants, Membrane
complexes proteases, damage
Micro- mediators of Activated
inflammation
organisms C1q macrophages Plate 4.4
Antigen (see plate B3)
C3a
C4a Inflammation
C5a
C3b Opsonization
of antigen Mediators of
Activation inflammation
Antigen
Membrane attack
complex (C5–C9) 4
Mast cells,
basophils
Na + 3 Antigen
H 2 O
Oxidants Eosinophils
Proteases
Na + Perforins
H 2 O
Antigen:
Pathogen, Natural
foreign cell, killer cell
virus-infected
endogenous cell
ADCC IgA
Cytolysis IgE IgE IgM IgG
Fc receptor IgG
Fc
IgG Immunglobulins 95
(see plate C3)
Despopoulos, Color Atlas of Physiology © 2003 Thieme
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