Page 67 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

D. Effect of IPSP on postsynaptic stimulation

AP E
Excitatory
transmitter mV
–70
EPSP ms AP I
Nerve and Muscle, Physical Work Depolarization Inhibitory –70 IPSP
–90
+
K
transmitter
+
Na
–90
Electrotonic transmission
“Short-circuit” via
–
+
mV
EPSP+IPSP
2 K - (and/or Cl -) channels K + –70 Summation
Hyperpolarization
–90
ms
Postsynaptic
neuron Electrotonic currents
hyperpolarize
axon hillock To
axon hillock
E. Termination of transmitter action
Extraneuronal
uptake
Reuptake Glial cell, etc.
Inhibition
Presynaptic of exocytose
ending Diffusion
out of cleft
g K g Ca
Autoceptor

Postsynaptic
cell
Enzymatic breakdown
of transmitter Rapid inactivation of
cation channel
(desensitization) Internalization
54 of receptor
Despopoulos, Color Atlas of Physiology © 2003 Thieme
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