Page 68 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

F. Neurotransmitters in the central nervous system
Transmitter Receptor Receptor Effect
subtypes types Ion conductance Second messenger
Na + K + Ca 2+ Cl – cAMP IP 3 /DAG
Acetylcholine Nicotinic
Muscarinic:
M1,
M2, M3
ADH V1
(= vasopressin) V2 Synaptic Transmission III u. IV
CCK (= cholecystokinin) CCK A–B
Dopamine D1, D5
D2
GABA GABA A ,GABA C
(= γ-aminobutyric acid) GABA B

Glutamate(aspartate) AMPA
Kainat
NMDA Plate 2.7 u. 2.8
m-GLU
Glycine _
Histamine H 1
H 2
Neurotensin _
Norepinephrine, α 1(A–D)
epinephrine α 2(A–C)
β 1–3
Neuropeptide Y (NPY) Y1–2
Opioid peptides µ, δ, κ
Oxytocin _
Purines P 1 : A 1
A 2a
P 2X
P 2Y
Serotonin 5-HT 1
(5-hydroxytryptamine) 5-HT 2
5-HT 3
5-HT 4–7
Somatostatin (= SIH) SRIF
Tachykinin NK1–3

Amino acids Inhibits or promotes
Catecholamines
Peptides Ionotropic receptor Metabotropic receptor DAG
(ligand-gated (G protein-mediated cAMP
Others ion channel) effect) ATP PIP 2 IP 3 55
(Modified from F. E. Bloom)
Despopoulos, Color Atlas of Physiology © 2003 Thieme
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