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                  490    P A R T  III / Assessment of Heart Disease
                  Table 21-10 ■ DOPPLER INDICES
                  Indices            Normal Value                Interpretation
                  Flow time corrected  330–360                   Correction in flow time for HR. The FT c is an indicator of preload. 311 The FTc
                    (FT c )           milliseconds                 may also be affected by factors that affect vascular resistance. 357  Example: ↓ FT c
                                                                   (narrow base of waveform)—hypovolemia/decreased preload (may reflect changes
                                                                   in preload or preload-CO-induced changes in vascular resistance).
                                                                   ↑ FT c —increased preload—decreasing vascular resistance.
                  Peak velocity (PV)  Age         PV (cm/s)  MA  Peak velocity of blood (apex of waveform) during the systolic ejection phase.
                                     20           90–120   15.6  Provides an index of contractility. ↑ PV—increased contractility
                                     30           85–115   14.9
                  Mean acceleration (MA)  40      80–110   14.1  MA: Maximum slope of the velocity curve as a function of time (derivative of the
                                     50           70–100   12.7    velocity). Indicator of contractility.
                                     60           60–90    11.2
                                     70           50–80    9.7
                                     80           40–70    8.2   *↑ afterload: ↓ PV (decreased contractile force) and ↓ FTc (decreased ejection time)
                                     90           30–60    6.7
                  volume status and SV has been shown to decrease postoperative  Echocardiography
                  morbidity and mortality and length of hospital stay after major
                  abdominal and orthopedic surgery. 358–361           Doppler echocardiography provides information on CO and esti-
                     EDM also can be used to guide postoperative or ICU man-  mates of intracardiac pressures, global and regional LV and RV
                  agement. In patients undergoing emergent cardiac surgery, the  systolic and diastolic function, end-diastolic area (preload), and
                                                                                                 367
                  best indicators of postoperative morbidity and mortality were  regional wall motion abnormalities.  Echocardiography is also
                  the SV ( 60 mL) and increased HR ( 90 beats per minute) at  useful in the diagnosis of traumatic aortic injury after blunt chest
                  the time of admission to the ICU, both of which can be moni-  trauma, cardiac tamponade, mechanical complications after an
                  tored with EDM. 362  However, application of these indicators in  acute MI (e.g., mitral valve dysfunction, free wall rupture, septal
                  another study failed to find similar results and highlight the im-  defect), sepsis-induced myocardial dysfunction, and the cause of a
                                                                                                   368–370
                  portance of other hemodynamic indices (PA pressures) in predict-  pulseless electrical activity cardiac arrest.  Echocardiography
                  ing outcomes. 363  In a nurse-led study, 174 post-cardiac surgery  or the measurement of CO should be considered in patients with
                  patients received postoperative management guided by EDM to  clinical evidence of ventricular failure and persistent shock despite
                                                                                           166
                                               2
                  maintain a SVI above 35 mL/min/m compared with care di-  adequate fluid resuscitation.
                  rected by standard hemodynamic monitoring. There was a sig-
                  nificant decrease in the length of hospital stay in the EDM  TEE in the ICU
                  group (median 9 to 7 days), ICU bed usage decreased by 23%  In the ICU, TEE rather than transthoracic echocardiography may
                  and there was a trend toward decreased postoperative complica-  be necessary when there is interference with imaging caused by
                  tions. 364  In a study of trauma patients, standardized resuscita-  subcutaneous air, chest wall edema, the presence of mediastinal or
                  tion during the first 12 hours of ICU care was guided by the  pleural tubes, mechanical ventilation, or surgical dressings. TEE is
                  achievement of standard endpoints (e.g., MAP, CVP) or stan-  typically used for a single monitoring event in sedated/anesthetized
                  dard endpoints plus EDM parameters (FTc and SV). Compared  patients. The use of TEE improves diagnostic accuracy in critically
                  with the standard care group, the EDM group received more  ill patients compared with PA catheter-derived diagnosis, particu-
                  colloids, but similar amounts of crystalloids and blood in the  larly in cases of unexplained hypotension, abnormal ventricular
                  first 24 hours, had significantly lower lactate levels at 12 and  function, cardiac tamponade, and the determination of preload
                  24 hours, had fewer infectious complications, and had a shorter  status. 371–374  However, results are variable from studies comparing
                  length of ICU and hospital stay. However, there was no signifi-  the agreement and correlation of TEE–CO with TDCO and
                  cant difference in organ dysfunction or in ICU mortality or hos-  Fick–CO measurements; 375–377  thus, CO–TEE can be used to fol-
                  pital mortality between the EDM and conventional monitoring  low trends, but caution must be taken when interpreting absolute
                  groups. 365  In addition, in critically ill patients, the use of EDM  values.
                  improved diagnostic accuracy by ICU physicians (the physicians  TEE also can be used to evaluate respiratory-induced changes
                  correctly predicted the CI in only 44% of patients) and led to a  in peak aortic flow velocity and vena caval diameter as indicators
                  change in therapy in 54% of the patients.  366  These studies  of preload responsiveness. 378,379  However, ventricular volume
                  demonstrate the safety of the EDM, the potential utility in iden-  measurement (left ventricular end-diastolic area) does not predict
                  tifying high-risk patients, the ability of critical care nurses to  fluid responsiveness, 235  which highlights the difference between
                  place and monitor the patient using TEE, and potentially im-  preload and preload responsiveness.
                  proved outcomes associated with the integration of additional  Although TEE is a relatively safe procedure, complications
                  TEE-derived hemodynamic indices (SV, FT c ) to standard out-  can occur (major complications  0.02%). 380  The patient should
                  come measures.                                      be monitored for hypotension, arrhythmias, and vomiting and
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