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C HAPTER 2 7 / Sudden Cardiac Death and Cardiac Arrest 653
19. Kadish, A., Dyer, A., Daubert, J. P., et al. (2004). Prophylactic defibrilla-
SUMMARY tor implantation in patients with non-ischemic dilated cardiomyopathy.
New England Journal of Medicine, 350, 2151–2158.
20. Zipes, D. P., et al. (2006). ACC/AHA/ESC 2006 Guidelines for manage-
Sudden cardiac death remains the primary cause of cardiac death in ment of patients with ventricular arrhythmias and the prevention of
the United States, despite all the advances in therapy and technology. sudden cardiac death. Journal of American College of Cardiology, 48(5),
247–346.
At present, the pathophysiology of SCD is not clearly understood. 21. Maron, B. J. (2002). Hypertrophic cardiomyopathy—cardiology patient
Progress has been made on the genotype-phenotype correlations of page. Circulation, 106, 2419–2421.
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LQTS patients and other inheriteddiseases linking genetic substrate 22. Maron, B. J., Seidman, J. G., & Seidman, C. E. (2004). Viewpoint—Pro-
as a marker for SCD. Riskfactor stratification and an understanding posal for contemporary screening strategies in families with hypertrophic
of pathophysiology remain critically deficient. SCD will remain a cardiomyopathy. Journal of the American College of Cardiology, 44(11),
2125–2132.
deadly challenge until these problems are solved. Education and 23. Turakhia, M., & Tseng, Z. H. (2007). Sudden cardiac death: Epidemiology,
training should continue to focus on initiating the “chain of survival” mechanisms, and therapy. Current Problems in Cardiology, 32, 501–546.
stressing the importance of CPR, andfocusing on post-resuscitation 24. Imboden, M., Swan, H., Denjoy, I., et al. (2006). Female predominance
guidelines to increase survival rates for sudden cardiac arrest patients. and transmission distortion in the long-QT syndrome. New England Jour-
Stressing prevention is vital because the first symptom is often death. nal of Medicine, 355(26), 2744–2751.
25. Napolitano, C., Priori, S. G., & Schwartz, P. J. (2005). Genetic testing in
the long QT syndrome—Development and validation of an efficient ap-
proach to genotyping in clinical practice. JAMA, 294(23), 2975–2981.
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2. Callans, D. J. (2002). Management of the patient who has been resusci- 27. Priori, S. G., Napolitano, C., Gasparini, M., et al. (2000). Clinical and ge-
tatedfrom sudden cardiac death. Circulation, 105, 2704–2707. netic heterogeneity of right bundle branch block and ST-segment eleva-
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