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                                                                  C HAPTER  32 / Coronary Heart Disease Risk Factors  759
                                                                                         Women
                                                                        Caucasian      African-American  Mexican-American
                                                                  30
                                                                 ≥ 4 times/week  25
                                                                  20
                                                                 Percent walking  15
                                                                  10
                                                                   5
                                                                   0
                   ■ Figure 32-6 Prevalence of walking at least 1 mile with-  20–29  30–39  40–49  50–59  60–69  70+
                   out stopping at least four times per week among U.S.  A                  Age
                   women (A) and men (B) by age and race/ethnicity. (From
                   National Center for Health Statistics. National Health and             Men
                   Nutrition Examination Survey, III, 1988–1994.)
                                                                        Caucasian      African-American  Mexican-American
                                                                 30
                                                                  4 times/week  25
                                                                 20
                                                                 15
                                                                Percent walking  10
                                                                  5
                                                                  0
                                                                      20–29    30–39   40–49   50–59    60–69    70+
                                                               B                            Age
                   and women, 59  and ischemic heart disease (fatal and nonfatal MI  fasting blood glucose of at least 126 mg/dL (Expert Committee,
                   plus sudden death) in men. 62  Although pooled analyses from  1997). Currently over 23 million people or about 7.8% of the to-
                   randomized trials of comprehensive cardiac rehabilitation suggest  tal U.S. population are estimated to have diabetes; about 17.9
                   a 19% to 25% reduction in mortality rates associated with reha-  million have been diagnosed and 5.7 million are unaware that
                   bilitation, it is difficult to dissociate the benefits of the exercise  they have the disease (Centers for Disease Control and Preven-
                   component of these programs from other lifestyle changes. 63,64  tion, 2008). Approximately 90% to 95% of adults have type 2
                   However, the potential benefits of a program of regular exercise af-  diabetes; it is estimated that total diabetes prevalence will more
                   ter MI include an increase in exercise capacity, decrease in angina,  than double between 2005 and 2050 (Narayan, 2006). Diabetes
                   improved control of other cardiovascular disease risk factors, de-  is more prevalent in minority populations. The prevalence of dia-
                   creased anxiety and depression, and increased self-esteem and  betes has been consistently higher in black and Hispanic than in
                   sense of well-being. 64  A large systematic review and meta-analysis  white populations (Fig. 32-7). Prevalence tended to be higher in
                   of randomized controlled trials of exercise-based rehabilitation for  individuals aged 65 years and older, and lowest among those less
                   patients with CHD confirmed the benefits of exercise-based car-  than 45 years of age regardless of race.
                                 65
                   diac rehabilitation. Exercise training is also recognized as an im-  Diabetes is associated with increased rates of virtually all forms
                   portant adjunctive therapy, with similar benefits for those with a  of cardiovascular disease. 67  In men, diabetes is associated with a
                   history of congestive heart failure. 66  Activity and exercise are dis-  doubling in CHD incidence, and in women with diabetes, CHD
                   cussed further in Chapter 37.                       incidence is five to seven times that of women without diabetes. 24,68
                                                                       Diabetes doubles the rate of MI in men and increases the rate of MI
                                                                       in women four to six fold. 24,26,68  CHD and MI rates in diabetic
                                                                       women approach those of men of similar age, essentially eliminat-
                      DIABETES MELLITUS                                ing the advantage found in nondiabetic women compared with
                                                                                          69
                                                                                                          70
                                                                       men. This is true for white, Mexican-American, and Japanese 71
                   The American Diabetes Association diagnostic criteria for dia-  women. Ischemic heart disease mortality is doubled in men with
                   betes mellitus are random blood glucose of at least 200 mg/dL or  diabetes and tripled in women with diabetes. 72
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