Page 53 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Nonspecific Immune Defense (Enhanced by Specific Antibodies)
Humoral Cellular
Lysozyme Receptors
for Fc and C3b
Damaged membranes
Interferons (IFN)
Neutrophil
IFNα, β, γ inhibit leukocytes,
virus proliferation monocytes Ig
IFNγ activates macrophages, → macrophages 2 Antigen C3b
killer cells, I
Antigen
B and T cells opsonification
Phagocytosis by Ig and C3b
Complement activation Defense
1
alternative classical
C3 C1q Lysis
Liberate: Immune
Antigen-antibody oxidants Membrane
complexes proteases damage
Micro- inflammation Activated
mediators
organisms C1q makrophages Plate 3.8
Antigen (see B6)
C3a
C4a Inflammation
C5a
C3b Antigen
opsonification Inflammation
Activation mediators
Antigen
Membrane attack
complex (C5–C9) 4
Mast cells,
basophil
leukocytes
Na + 3 Antigen
H 2 O
Oxidants Eosinophil
Proteases leukocytes
Na + Perforins
Antigen: H 2 O
pathogen, Natural
foreign cell, killer cell
virus infected
body cell

ADCC IgA
Cytolysis IgE IgM IgG
IgE
Fc receptor IgG
Fc
IgG Immunglobulins 43
(see B5)

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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