Page 67 - Concise Pathology for Exam Preparation ( PDFDrive )

52 SECTION I General Pathology

Proliferating
blood vessels

Chronic
inflammatory
cells

FIGURE 2.10. Section showing granulation tissue components (congested capillaries in an
oedematous background with plasma cells, lymphocytes, histiocytes and fibroblasts).

Q. Differentiate between granulation tissue and granuloma.

Ans. Differences between granulation tissue and granuloma are shown in Table 2.2.

TABLE 2.2. Differences between granulation tissue and granuloma

Features Granulation tissue Granuloma
Component of Healing and repair Chronic inflammation; occurs due to delayed
hypersensitivity response
Definition Tissue composed of newly formed Microscopic aggregation of macrophages that are
blood vessels (angiogenesis), transformed into epithelium like (epithelioid
proliferating fibroblasts and cells) surrounded by a collar of mononuclear
chronic inflammatory cells cells (lymphocytes and plasma cells)
Older granulomas have an enclosing rim of fibro-
blasts and connective tissue
Giant cells Not seen Epithelioid cells fuse to form ‘Langhans giant
cells’ 40–50 microns in size with 20 or more
nuclei arranged peripherally
Remodelling (mat- Seen Not seen
uration and re-
organization of
fibrous tissue)
Growth factors Angiogenic and fibrogenic Involvement of cytokines like IL-1, IL-12 and
growth factors involved, eg, gIFN
PDGF, FGF, TNF and VEGF

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