Page 1969 - Hematology_ Basic Principles and Practice ( PDFDrive )

Chapter 114 Principles of Neutrophil (Granulocyte) Transfusions 1743

10
2. Collect PMNs (4 to 8 × 10 ) from allogeneic blood donors, as transplantation, granulocyte colony-stimulating factor-mobilized granu-
follows: locytes, and liposomal amphotericin-B. Blood 92:2719, 1998.
a. Stimulate neutrophilia by giving the donor 300 to 480 µg 13. Bielorai B, Toren A, Wolach B, et al: Successful treatment of invasive
G-CSF subcutaneously plus 8 mg dexamethasone orally 12 aspergillosis in chronic granulomatous disease by granulocyte transfu-
hours (±4 hours) before beginning leukapheresis; sions followed by peripheral blood stem cell transplantation. Bone
b. Process 10 L of donor blood using a continuous-flow blood Marrow Transplant 26:1025, 2000.
separator with citrated hydroxyethyl starch solution infused 14. Bielorai B, Neumann Y, Avigad I, et al: Successful treatment of
throughout the entire collection. vancomycin-resistant Enterococcus sepsis in a neutropenic patient with
10
3. Transfuse one granulocyte concentrate (4 to 8 × 10 PMNs) daily G-CSF–mobilized granulocyte transfusions. Med Pediatr Oncol 34:221,
9
until bone marrow recovery (blood PMNs >1.0 × 10 /L without 2000.
granulocyte transfusion) or clinical resolution of infection. 15. Grigg A, Vecchi L, Bardy P, et al: G-CSF stimulated donor granulocyte
collections for prophylaxis and therapy of neutropenic sepsis. Aust N Z
J Med 26:813, 1996.
REFERENCES 16. Peters C, Minkov M, Matthes-Martin S, et al: Leucocyte transfusions
from rhG-CSF or prednisolone stimulated donors for treatment of severe
1. Alavi JB, Root RK, Djerassi I, et al: A randomized clinical trial of infections in immunocompromised neutropenic patients. Br J Haematol
granulocyte transfusions for infection in acute leukemia. N Engl J Med 106:689, 1999.
296:706, 1977. 17. Price TH, Bowden RA, Boeckh M, et al: Phase I/II trial of neutrophil
2. Fortuny IE, Bloomfield CD, Hadlock DC, et al: Granulocyte transfusion: transfusions from donors stimulated with G-CSF and dexamethasone
A controlled study in patients with acute non-lymphocytic leukemia. for treatment of patients with infections in hematopoietic stem cell
Transfusion 15:548, 1975. transplantation. Blood 95:3302, 2000.
3. Graw RG, Jr, Herzig G, Perry S, et al: Normal granulocyte transfusion 18. Lee J-J, Chung I-J, Park M-R, et al: Clinical efficacy of granulocyte
therapy. N Engl J Med 287:367, 1972. transfusion therapy in patients with neutropenia-related infections.
4. Herzig RH, Herzig GP, Graw RG, Jr, et al: Successful granulocyte Leukemia 15:203, 2001.
transfusion therapy for gram-negative septicemia. N Engl J Med 396:702, 19. Hubel K, Carter RA, Liles WC, et al: Granulocyte transfusion therapy
1977. for infections in candidates and recipients of HPC transplantation: A
5. Higby DJ, Yates JW, Henderson ES, et al: Filtration leukapheresis for comparative analysis of feasibility and outcome for community versus
granulocytic transfusion therapy. N Engl J Med 292:761, 1975. related donors. Transfusion 42:1414, 2002.
6. Vogler WR, Winton EF: A controlled study of the efficacy of granulocyte 20. Safdar A, Hanna HA, Boktour M, et al: Impact of high-dose granulocyte
transfusions in patients with neutropenia. Am J Med 63:548, 1977. transfusions in patients with cancer with candidemia. Cancer 101:2859,
7. Winston DJ, Ho WG, Gale RP: Therapeutic granulocyte transfusions 2004.
for documented infections: A controlled trial in 95 infectious granulo- 21. Seidel MG, Peters C, Wacker A, et al: Randomized phase III study of
cytopenic episodes. Ann Intern Med 97:509, 1982. granulocyte transfusions in neutropenic patients. Bone Marrow Trans-
8. Vamvakas EC, Pineda AA: Meta-analysis of clinical studies of the efficacy plant 42:679, 2008.
of granulocyte transfusions in the treatment of bacterial sepsis. J Clin 22. Price TH, Boeckh M, Harrison RW, et al: Efficacy of transfusion with
Apher 11:1, 1996. granulocytes from G-CSF/dexamethasone treated donors in neutropenic
9. Clarke K, Szer J, Shelton M, et al: Multiple granulocyte transfusions patients with infection. Blood First Edition Paper, prepublished online
facilitating unrelated bone marrow transplantation in a patient with very Sept 2, 2015; doi: 10.1182/blood-2015-05-645986.
severe aplastic anemia complicated by suspected fungal infection. Bone 23. Strauss RG: Current status of granulocyte transfusions to treat neonatal
Marrow Transplant 16:723, 1995. sepsis. J Clin Apher 5:25, 1989.
10. Hester JP, Dignani MC, Anaissie EJ, et al: Collection and transfusion of 24. Adkins D, Spitzer G, Johnston M, et al: Transfusions of granulocyte-
granulocyte concentrates from donors primed with granulocyte stimulat- colony-stimulating factor-mobilized granulocyte components to alloge-
ing factor and response of myelosuppressed patients with established neic transplant recipients: Analysis of kinetics and factors determining
infection. J Clin Apher 10:188, 1995. posttransfusion neutrophil and platelet counts. Transplantation 37:737,
11. Catalano L, Fontant R, Scarpato N, et al: Combined treatment with 1997.
amphotericin-B and granulocyte transfusion from G-CSF-stimulated 25. Adkins DR, Goodnough LT, Shenoy S, et al: Effect of leukocyte compat-
donors in an aplastic patient with invasive aspergillosis undergoing bone ibility on neutrophil increment after transfusion of granulocyte colony-
marrow transplantation. Haematologica 82:71, 1997. stimulating factor-mobilized prophylactic granulocyte transfusions and
12. Ozsahin H, von Planta M, Muller I, et al: Successful treatment of on clinical outcomes after stem cell transplantation. Blood 95:3605,
invasive aspergillosis in chronic granulomatous disease by bone marrow 2000.