Page 316 - Hematology_ Basic Principles and Practice ( PDFDrive )
P. 316
260.e4 Part III Immunologic Basis of Hematology
136. Hawiger D, et al: Dendritic cells induce peripheral T cell unresponsive- 158. Ochando JC, et al: Alloantigen-presenting plasmacytoid dendritic cells
ness under steady state conditions in vivo. J Exp Med 194:769–779, mediate tolerance to vascularized grafts. Nat Immunol 7:652–662,
2001. 2006. doi: 10.1038/ni1333.
137. Probst HC, McCoy K, Okazaki T, et al: Resting dendritic cells induce 159. Graesser D, et al: Altered vascular permeability and early onset of
+
peripheral CD8 T cell tolerance through PD-1 and CTLA-4. Nat experimental autoimmune encephalomyelitis in PECAM-1-deficient
Immunol 6:280–286, 2005. doi: 10.1038/ni1165. mice. J Clin Invest 109:383–392, 2002. doi: 10.1172/JCI13595.
138. Grohmann U, Fallarino F, Puccetti P: Tolerance, DCs and tryptophan: 160. Tada Y, et al: Acceleration of the onset of collagen-induced arthritis by
much ado about IDO. Trends Immunol 24:242–248, 2003. a deficiency of platelet endothelial cell adhesion molecule 1. Arthritis
139. Mahnke K, et al: The dendritic cell receptor for endocytosis, DEC-205, Rheum 48:3280–3290, 2003. doi: 10.1002/art.11268.
can recycle and enhance antigen presentation via major histocompat- 161. Clement M, et al: CD31 is a key coinhibitory receptor in the devel-
ibility complex class II-positive lysosomal compartments. J Cell Biol opment of immunogenic dendritic cells. Proc Natl Acad Sci USA
151:673–684, 2000. 111:E1101–E1110, 2014. doi: 10.1073/pnas.1314505111.
140. Zlotnikov-Klionsky Y, et al: perforin-positive dendritic cells exhibit an 162. Zheng J, et al: MicroRNA-23b promotes tolerogenic properties of den-
immuno-regulatory role in metabolic syndrome and autoimmunity. dritic cells in vitro through inhibiting Notch1/NF-κB signalling pathways.
Immunity 43:776–787, 2015. doi: 10.1016/j.immuni.2015.08.015. Allergy 67:362–370, 2012. doi: 10.1111/j.1398-9995.2011.02776.x.
141. Bar-On L, Birnberg T, Kim KW, et al: Dendritic cell-restricted 163. Oderup C, LaJevic M, Butcher EC: Canonical and noncanonical Wnt
CD80/86 deficiency results in peripheral regulatory T-cell reduction proteins program dendritic cell responses for tolerance. J Immunol
but is not associated with lymphocyte hyperactivation. Eur J Immunol 190:6126–6134, 2013. doi: 10.4049/jimmunol.1203002.
41:291–298, 2011. doi: 10.1002/eji.201041169. 164. Kaji R, Kiyoshima-Shibata J, Nagaoka M, et al: Bacterial teichoic acids
142. Hori S, Nomura T, Sakaguchi S: Control of regulatory T cell develop- reverse predominant IL-12 production induced by certain lactobacillus
ment by the transcription factor Foxp3. Science 299:1057–1061, 2003. strains into predominant IL-10 production via TLR2-dependent ERK
doi: 10.1126/science.1079490. activation in macrophages. J Immunol 184:3505–3513, 2010. doi:
+
143. Houot R, Perrot I, Garcia E, et al: Human CD4 CD25 high regulatory T 10.4049/jimmunol.0901569.
cells modulate myeloid but not plasmacytoid dendritic cells activation. 165. Ohnmacht C, et al: Constitutive ablation of dendritic cells breaks self-
J Immunol 176:5293–5298, 2006. tolerance of CD4 T cells and results in spontaneous fatal autoimmunity.
+
144. Schildknecht A, et al: FoxP3 regulatory T cells essentially contribute J Exp Med 206:549–559, 2009. doi: 10.1084/jem.20082394.
+
to peripheral CD8 T-cell tolerance induced by steady-state dendritic 166. Chung CY, Ysebaert D, Berneman ZN, et al: Dendritic cells: cel-
cells. Proc Natl Acad Sci USA 107:199–203, 2010. doi: 10.1073/ lular mediators for immunological tolerance. Clin Dev Immunol
pnas.0910620107. 2013:972865, 2013. doi: 10.1155/2013/972865.
145. Muth S, Schutze K, Schild H, et al: Release of dendritic cells from 167. Liu J, Cao X: Regulatory dendritic cells in autoimmunity: a com-
+
cognate CD4 T-cell recognition results in impaired peripheral toler- prehensive review. J Autoimmun 63:1–12, 2015. doi: 10.1016/j.
ance and fatal cytotoxic T-cell mediated autoimmunity. Proc Natl Acad jaut.2015.07.011.
Sci USA 109:9059–9064, 2012. doi: 10.1073/pnas.1110620109. 168. Carreno LJ, Pacheco R, Gutierrez MA, et al: Disease activity in systemic
146. Manches O, Fernandez MV, Plumas J, et al: Activation of the nonca- lupus erythematosus is associated with an altered expression of low-affinity
nonical NF-κB pathway by HIV controls a dendritic cell immunoregu- Fc γ receptors and costimulatory molecules on dendritic cells. Immunol-
latory phenotype. Proc Natl Acad Sci USA 109:14122–14127, 2012. ogy 128:334–341, 2009. doi: 10.1111/j.1365-2567.2009.03138.x.
doi: 10.1073/pnas.1204032109. 169. Mozaffarian N, Wiedeman AE, Stevens AM: Active systemic lupus
147. Probst HC, Muth S, Schild H: Regulation of the tolerogenic function erythematosus is associated with failure of antigen-presenting cells
of steady-state DCs. Eur J Immunol 44:927–933, 2014. doi: 10.1002/ to express programmed death ligand-1. Rheumatology (Oxford)
eji.201343862. 47:1335–1341, 2008. doi: 10.1093/rheumatology/ken256.
148. Fallarino F, et al: Modulation of tryptophan catabolism by regulatory 170. Ganguly D, Haak S, Sisirak V, et al: The role of dendritic cells in
T cells. Nat Immunol 4:1206–1212, 2003. doi: 10.1038/ni1003. autoimmunity. Nat Rev Immunol 13:566–577, 2013. doi: 10.1038/
149. Liang B, et al: Regulatory T cells inhibit dendritic cells by lymphocyte nri3477.
activation gene-3 engagement of MHC class II. J Immunol 180:5916– 171. Wan S, Zhou Z, Duan B, et al: Direct B cell stimulation by dendritic
5926, 2008. cells in a mouse model of lupus. Arthritis Rheum 58:1741–1750, 2008.
150. Laouar Y, et al: TGF-β signaling in dendritic cells is a prerequisite for doi: 10.1002/art.23515.
the control of autoimmune encephalomyelitis. Proc Natl Acad Sci USA 172. Sang A, et al: Dysregulated cytokine production by dendritic cells
105:10865–10870, 2008. doi: 10.1073/pnas.0805058105. modulates B cell responses in the NZM2410 mouse model of lupus.
+
+
151. Mahnke K, Qian Y, Knop J, et al: Induction of CD4 /CD25 regula- PLoS ONE 9:e102151, 2014. doi: 10.1371/journal.pone.0102151.
tory T cells by targeting of antigens to immature dendritic cells. Blood 173. Pascual V, Farkas L, Banchereau J: Systemic lupus erythematosus: all
101:4862–4869, 2003. doi: 10.1182/blood-2002-10-3229. roads lead to type I interferons. Curr Opin Immunol 18:676–682, 2006.
152. Hugues S, et al: Tolerance to islet antigens and prevention from doi: 10.1016/j.coi.2006.09.014.
diabetes induced by limited apoptosis of pancreatic β cells. Immunity 174. Farkas L, Beiske K, Lund-Johansen F, et al: Plasmacytoid dendritic
16:169–181, 2002. cells (natural interferon- α/β-producing cells) accumulate in cutaneous
153. Verbovetski I, et al: Opsonization of apoptotic cells by autologous iC3b lupus erythematosus lesions. Am J Pathol 159:237–243, 2001.
facilitates clearance by immature dendritic cells, down-regulates DR 175. Bennett L, et al: Interferon and granulopoiesis signatures in systemic
and CD86, and up-regulates CC chemokine receptor 7. J Exp Med lupus erythematosus blood. J Exp Med 197:711–723, 2003. doi:
196:1553–1561, 2002. 10.1084/jem.20021553.
154. Frleta D, et al: HIV-1 infection-induced apoptotic microparticles 176. Blomberg S, et al: Presence of cutaneous interferon-α producing cells
inhibit human DCs via CD44. J Clin Invest 122:4685–4697, 2012. in patients with systemic lupus erythematosus. Lupus 10:484–490,
doi: 10.1172/JCI64439. 2001.
155. Rutella S, Danese S, Leone G: Tolerogenic dendritic cells: cytokine 177. Gilliet M, Cao W, Liu YJ: Plasmacytoid dendritic cells: sensing nucleic
modulation comes of age. Blood 108:1435–1440, 2006. doi: 10.1182/ acids in viral infection and autoimmune diseases. Nat Rev Immunol
blood-2006-03-006403. 8:594–606, 2008. doi: 10.1038/nri2358.
156. Curiel TJ, et al: Blockade of B7-H1 improves myeloid dendritic 178. Pettit AR, Thomas R: Dendritic cells: the driving force behind autoim-
cell-mediated antitumor immunity. Nat Med 9:562–567, 2003. doi: munity in rheumatoid arthritis? Immunol Cell Biol 77:420–427, 1999.
10.1038/nm863. doi: 10.1046/j.1440-1711.1999.00855.x.
157. Wakkach A, et al: Characterization of dendritic cells that induce 179. Ludewig B, Odermatt B, Landmann S, et al: Dendritic cells induce
tolerance and T regulatory 1 cell differentiation in vivo. Immunity autoimmune diabetes and maintain disease via de novo formation of
18:605–617, 2003. local lymphoid tissue. J Exp Med 188:1493–1501, 1998.

