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138  Part III:  Epochal Hematology                                 Chapter 9:  Hematology in Older Persons            139




                    132. Linton PJ, Dorshkind K: Age-related changes in lymphocyte development and func-    166. Lamberts SW, van den Beld AW, van der Lely AJ: The endocrinology of aging. Science
                     tion. Nat Immunol 5(2):133–139, 2004.                 278(5337):419–424, 1997.
                    133. Haq K, McElhaney JE: Immunosenescence: Influenza vaccination and the elderly. Curr     167. French RA, Broussard SR, Meier WA, et al: Age-associated loss of bone marrow
                     Opin Immunol 29C:38–42, 2014.                         hematopoietic cells is reversed by GH and accompanies thymic reconstitution. Endo-
                    134. Pritz T, Weinberger B, Grubeck-Loebenstein B: The aging bone marrow and its impact   crinology 143(2):690–699, 2002.
                     on immune responses in old age. Immunol Lett 162(1 Pt B):310–315, 2014.    168. Nissenson AR, Goodnough LT, Dubois RW: Anemia: Not just an innocent bystander?
                    135. Hartsock  RJ,  Smith  EB,  Petty  CS:  Normal  variations with aging of  the  amount  of   Arch Intern Med 163(12):1400–1404, 2003.
                     hematopoietic tissue in bone marrow from the anterior iliac crest. A study made from     169. Balducci L, Ershler WB, Bennett JM, editors: Anemia in the Elderly. Springer, New York,
                     177 cases of sudden death examined by necropsy. Am J Clin Pathol 43:326–331, 1965.  2007.
                    136. Ricci C, Cova M, Kang YS, et al: Normal age-related patterns of cellular and fatty bone     170. Blanc B, Finch CA, Hallberg L: Nutritional anaemias. Report of a WHO Scientific
                     marrow distribution in the axial skeleton: MR imaging study. Radiology 177(1):83–88, 1990.  Group. World Health Organ Tech Rep Ser 405:1–40, 1968.
                    137. Steinmann GG, Klaus B, Muller-Hermelink HK: The involution of the ageing human     171. Ania BJ, Suman VJ, Fairbanks VF, et al: Incidence of anemia in older people: An epi-
                     thymic epithelium is independent of puberty. A morphometric study. Scand J Immunol   demiologic study in a well-defined population. J Am Geriatr Soc 45(7):825–831, 1997.
                     22(5):563–575, 1985.                                 172. Chaves PH, Ashar B, Guralnik JM,  Fried LP:  Looking at  the relationship between
                    138. Haynes  BF,  Sempowski GD, Wells  AF, Hale  LP: The  human thymus  during  aging.   hemoglobin concentration and prevalent mobility difficulty in older women. Should
                     Immunol Res 22(2–3):253–261, 2000.                    the criteria currently used to define anemia in older people be reevaluated? J Am Geri-
                    139. Woolthuis CM, de Haan G, Huls G: Aging of hematopoietic stem cells: Intrinsic   atr Soc 50(7):1257–1264, 2002.
                     changes or micro-environmental effects? Curr Opin Immunol 23(4):512–517, 2011.    173. Culleton BF, Manns BJ, Zhang J, et al: Impact of anemia on hospitalization and mortal-
                    140. Geiger H, Denkinger M, Schirmbeck R: Hematopoietic stem cell aging.  Curr Opin   ity in older adults. Blood 107(10):3841–3846, 2006.
                     Immunol 2014;29C:86–92.                              174. Izaks GJ, Westendorp RG, Knook DL: The definition of anemia in older persons. JAMA
                    141. Van Zant G, Liang Y: Concise review: Hematopoietic stem cell aging, life span, and   281(18):1714–1717, 1999.
                     transplantation. Stem Cells Transl Med 1(9):651–657, 2012.    175. Zakai NA, Katz R, Hirsch C, et al: A prospective study of anemia status, hemoglobin
                    142. Golub R, Cumano A: Embryonic hematopoiesis. Blood Cells Mol Dis 51(4):226–231,   concentration, and mortality in an elderly cohort: The Cardiovascular Health Study.
                     2013.                                                 Arch Intern Med 165(19):2214–2220, 2005.
                    143. Baron MH, Vacaru A, Nieves J: Erythroid development in the mammalian embryo.     176. Penninx BW, Pahor M, Woodman RC, Guralnik JM: Anemia in old age is associated
                     Blood Cells Mol Dis 51(4):213–219, 2013.              with increased mortality and hospitalization.  J Gerontol A Biol Sci Med Sci 61(5):
                    144. Bigas A, Guiu J, Gama-Norton L: Notch and Wnt signaling in the emergence of hemato-  474–479, 2006.
                     poietic stem cells. Blood Cells Mol Dis 51(4):264–270, 2013.    177. Beutler E, West C: Hematologic differences between African-Americans and whites:
                    145. Kurtzberg J, Denning SM, Nycum LM, et al: Immature human thymocytes can be   The roles of iron deficiency and alpha-thalassemia on hemoglobin levels and mean cor-
                     driven to differentiate into nonlymphoid lineages by cytokines from thymic epithelial   puscular volume. Blood 106(2):740–745, 2005.
                     cells. Proc Natl Acad Sci U S A 86(19):7575–7579, 1989.    178. Patel KV, Harris TB, Faulhaber M, et al: Racial variation in the relationship of anemia
                    146. Fowlkes BJ, Pardoll DM: Molecular and cellular events of T cell development.  Adv   with mortality and mobility disability among older adults. Blood 109(11):4663–4670,
                     Immunol 44:207–264, 1989.                             2007.
                    147. Rothenberg EV: The development of functionally responsive T cells.  Adv Immunol     179. Chaves PH, Xue QL, Guralnik JM, et al: What constitutes normal hemoglobin con-
                     51:85–214, 1992.                                      centration in community-dwelling disabled older women? J Am Geriatr Soc 52(11):
                    148. Geiger H, de Haan, G, Florian MC: The ageing of the haematopoietic stem cell com-  1811–1816, 2004.
                     partment. Nat Immunol 13:376–389, 2013.              180. Gaskell H, Derry S, Andrew Moore R, McQuay HJ: Prevalence of anaemia in older
                    149. Charbord P, Tavian M, Humeau L, Peault B: Early ontogeny of the human marrow from   persons: Systematic review. BMC Geriatr 8:1, 2008.
                     long bones: An immunohistochemical study of hematopoiesis and its microenviron-    181. Pandya N, Bookhart B, Mody SH, et al: Study of anemia in long-term care (SALT):
                     ment. Blood 87(10):4109–4119, 1996.                   Prevalence of anemia and its relationship with the risk of falls in nursing home resi-
                    150. Kuranda K, Vargaftig J, de la Rochere P, et al: Age-related changes in human hematopoi-  dents. Curr Med Res Opin 24(8):2139–2149, 2008.
                     etic stem/progenitor cells. Aging Cell 10(3):542–546, 2011.    182. Robinson B, Artz AS, Culleton B, et al: Prevalence of anemia in the nursing home:
                    151. Pang WW, Price EA, Sahoo D, et al: Human bone marrow hematopoietic stem cells   Contribution of chronic kidney disease. J Am Geriatr Soc 55(10):1566–1570, 2007.
                     are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci U S A     183. Artz AS, Thirman MJ: Unexplained anemia predominates despite an intensive evalua-
                     108(50):20012–20017, 2011.                            tion in a racially diverse cohort of older adults from a referral anemia clinic. J Gerontol
                    152. Harrison  DE, Astle CM:  Loss  of  stem cell repopulating  ability  upon  transplanta-  A Biol Sci Med Sci 66(8):925–932, 2011.
                     tion.  Effects  of  donor  age,  cell  number,  and  transplantation  procedure.  J Exp Med     184. Price EA, Mehra R, Holmes TH, Schrier SL. Anemia in older persons: Etiology and
                     156(6):1767–1779, 1982.                               evaluation. Blood Cells Mol Dis 46(2):159–165, 2011.
                    153. Harrison DE: Long-term erythropoietic repopulating ability of old, young, and fetal     185. Ferrucci L, Maggio M, Bandinelli S, et al: Low testosterone levels and the risk of anemia
                     stem cells. J Exp Med 157(5):1496–1504, 1983.         in older men and women. Arch Intern Med 166(13):1380–1388, 2006.
                    154. Rossi DJ, Bryder D, Zahn JM, et al: Cell intrinsic alterations underlie hematopoietic     186. Ferrucci L, Guralnik JM, Woodman RC, et al: Proinflammatory state and circulating
                     stem cell aging. Proc Natl Acad Sci U S A 102(26):9194–9199, 2005.  erythropoietin in persons with and without anemia. Am J Med 118(11):1288, 2005.
                    155. Beerman I, Maloney WJ, Weissmann IL, Rossi DJ: Stem cells and the aging hematopoi-    187. Artz AS, Fergusson D, Drinka PJ, et al: Mechanisms of unexplained anemia in the nurs-
                     etic system. Curr Opin Immunol 22:500–506, 2010.      ing home. J Am Geriatr Soc 52(3):423–427, 2004.
                    156. Liang Y, Van Zant G, Szilvassy SJ: Effects of aging on the homing and engraftment of     188. Strom  SS,  Velez-Bravo  V,  Estey  EH:  Epidemiology  of  myelodysplastic  syndromes.
                     murine hematopoietic stem and progenitor cells. Blood 106(4):1479–1487, 2005.  Semin Hematol 45(1):8–13, 2008.
                    157. Leng SX, Hung W, Cappola AR, et al: White blood cell counts, insulinlike growth fac-    189. Mori M, Murai Y, Hirai M, et al: Serum erythropoietin titers in the aged. Mech Ageing
                     tor-1 levels, and frailty in community-dwelling older women. J Gerontol A Biol Sci Med   Dev 1988;46(1–3):105–109, 2005.
                     Sci 2009;64A(4):499–502.                             190. Kario K, Matsuo T, Nakao K: Serum erythropoietin levels in the elderly. Gerontology
                    157a.   Welch JS, Ley, TJ, Link DC, et al: The origin and evolution of mutations in acute mye-  37(6):345–348, 1991.
                     loid leukemia. Cell 150:264–278, 2012.               191. Kario K, Matsuo T, Kodama K, Nakao K, Asada R: Reduced erythropoietin secretion in
                    158. Justesen J, Stenderup K, Ebbesen EN, et al: Adipocyte tissue volume in bone marrow   senile anemia. Am J Hematol 41(4):252–257, 1992.
                     is increased with aging and in patients with osteoporosis. Biogerontology 2(3):165–171,     192. Ershler WB, Sheng S, McKelvey J, et al: Serum erythropoietin and aging: A longitudinal
                     2001.                                                 analysis. J Am Geriatr Soc 53(8):1360–1365, 2005.
                    159. Verma S, Rajaratnam JH, Denton J, et al: Adipocytic proportion of bone marrow is     193. Lipschitz DA, Udupa KB, Milton KY, Thompson CO: Effect of age on hematopoiesis in
                     inversely related to bone formation in osteoporosis. J Clin Pathol 55(9):693–698, 2002.  man. Blood 63(3):502–509, 1984.
                    160. De Meyer T, De Buyzere ML, Langlois M, et al: Lower red blood cell counts in mid-    194. Nagel JE, Pyle RS, Chrest FJ, Adler WH: Oxidative metabolism and bactericidal capac-
                     dle-aged subjects with shorter peripheral blood leukocyte telomere length. Aging Cell   ity of polymorphonuclear leukocytes from normal young and aged adults. J Gerontol
                     7(5):700–705, 2008.                                   37(5):529–534, 1982.
                    161. Greider CW: Telomeres and senescence: The history, the experiment, the future. Curr     195. Leng SX, Xue QL, Tian J, et al: Inflammation and frailty in older women. J Am Geriatr
                     Biol 8(5):R178–81.                                    Soc 55(6):864–871, 2007.
                    162. Frenck RW Jr, Blackburn EH, Shannon KM: The rate of telomere sequence loss in     196. MacGregor RR, Shalit M: Neutrophil function in healthy elderly subjects. J Gerontol
                     human leukocytes varies with age. Proc Natl Acad Sci U S A 95(10):5607–5610, 1998.  45(2):M55–M60, 1990.
                    163. Gattermann N: Mitochondrial DNA mutations in the hematopoietic system. Leukemia     197. Rao  KM,  Currie  MS,  Padmanabhan  J,  Cohen  HJ:  Age-related alterations  in  actin
                     18(1):18–22, 2004.                                    cytoskeleton and receptor expression in human leukocytes. J Gerontol 47(2):B37–B44,
                    164. Kadenbach B, Munscher C, Frank V, et al: Human aging is associated with stochastic   1992.
                     somatic mutations of mitochondrial DNA. Mutat Res 338(1–6):161–172, 1995.    198. MacKinney AA Jr: Effect of aging on the peripheral blood lymphocyte count. J Gerontol
                    165. Bolognesi C, Abbondandolo A, Barale R, et al: Age-related increase of baseline fre-  33(2):213–216, 1978.
                     quencies of sister chromatid exchanges, chromosome aberrations, and micronuclei in     199. Pawelec G, Akbar A, Caruso C, et al: Human immunosenescence: Is it infectious?
                     human lymphocytes. Cancer Epidemiol Biomarkers Prev 6(4):249–256, 1997.  Immunol Rev 205:257–268, 2005.







          Kaushansky_chapter 09_p0129-0142.indd   139                                                                   17/09/15   6:16 pm
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