Page 166 - Williams Hematology ( PDFDrive )
P. 166

140  Part III:  Epochal Hematology                                 Chapter 9:  Hematology in Older Persons            141




                    263. Grubeck-Loebenstein  B,  Wick  G:  The  aging  of  the  immune  system.  Adv Immunol     282. Bernstein E, Kaye D, Abrutyn E, et al: Immune response to influenza vaccination in a
                     80:243–284, 2002.                                     large healthy elderly population. Vaccine 17(1):82–94, 1999.
                    264. Vallejo AN: Age-dependent alterations of the T cell repertoire and functional diversity     283. Gross PA, Quinnan GV Jr, Weksler ME, et al: Relation of chronic disease and immune
                     of T cells of the aged. Immunol Res 36(1–3):221–228, 2006.  response to influenza vaccine in the elderly. Vaccine 7(4):303–308, 1989.
                    265. Mascarucci P, Taub D, Saccani S, et al: Age-related changes in cytokine production by     284. McElhaney JE, Meneilly GS, Lechelt KE, et al: Antibody response to whole-virus and
                     leukocytes in rhesus monkeys. Aging (Milano) 13(2):85–94, 2001.  split-virus influenza vaccines in successful ageing. Vaccine 11(10):1055–1060, 1993.
                    266. Mascarucci P, Taub D, Saccani S, et al: Cytokine responses in young and old rhesus     285. Murasko DM, Bernstein ED, Gardner EM, et al: Role of humoral and cell-mediated
                     monkeys: Effect of caloric restriction. J Interferon Cytokine Res 22(5):565–571, 2002.  immunity in protection from influenza disease after immunization of healthy elderly.
                    267. Daynes RA, Araneo BA, Ershler WB, et al: Altered regulation of IL-6 production with   Exp Gerontol 2002;37(2–3):427–439, 1998.
                     normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone     286. Muszkat M, Friedman G, Dannenberg HD, et al: Response to influenza vaccination
                     and its sulfated derivative. J Immunol 150(12):5219–5230, 1993.  in community and in nursing home residing elderly: Relation to clinical factors. Exp
                    268. Fagiolo U, Cossarizza A, Scala E, et al: Increased cytokine production in mononuclear   Gerontol 38(10):1199–1203, 2003.
                     cells of healthy elderly people. Eur J Immunol 23(9):2375–2378, 1993.    287. Yamamoto K, Takeshita K, Shimokawa T, et al: Plasminogen activator inhibitor-1 is a
                    269. Kania DM,  Binkley N, Checovich M, et al: Elevated plasma levels of interleukin-6   major stress-regulated gene: Implications for stress-induced thrombosis in aged indi-
                     in postmenopausal women do not correlate with bone density.  J Am Geriatr Soc   viduals. Proc Natl Acad Sci U S A 99(2):890–895, 2002.
                     43(3):236–239, 1995.                                 288. Tracy RP, Bovill EG, Yanez D, et al: Fibrinogen and factor VIII, but not factor VII, are
                    270. Straub RH, Konecna L, Hrach S, et al: Serum dehydroepiandrosterone (DHEA) and   associated with measures of subclinical cardiovascular disease in the elderly. Results
                     DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA   from The Cardiovascular Health Study. Arterioscler Thromb Vasc Biol 15(9):1269–1279,
                     inhibits IL-6 secretion from mononuclear cells in man in vitro: Possible link between   1995.
                     endocrinosenescence and immunosenescence.  J Clin Endocrinol Metab 83(6):     289. Harris TB, Ferrucci L, Tracy RP, et al: Associations of elevated interleukin-6 and C-re-
                     2012–2017, 1998.                                      active protein levels with mortality in the elderly. Am J Med 106(5):506–512, 1999.
                    271. Young DG, Skibinski G, Mason JI, James K: The influence of age and gender on serum     290. Taaffe DR, Harris TB, Ferrucci L, et al: Cross-sectional and prospective relationships of
                     dehydroepiandrosterone sulphate (DHEA-S), IL-6, IL-6 soluble receptor (IL-6 sR) and   interleukin-6 and C-reactive protein with physical performance in elderly persons: Mac-
                     transforming growth factor beta 1 (TGF-beta1) levels in normal healthy blood donors.   Arthur studies of successful aging. J Gerontol A Biol Sci Med Sci 55(12):M709–M715,
                     Clin Exp Immunol 117(3):476–481, 1999.                2000.
                    272. Chorinchath BB, Kong LY, Mao L, McCallum RE: Age-associated differences in TNF-     291. Yaffe K, Lindquist K, Penninx BW, et al: Inflammatory markers and cognition in well-
                     alpha and nitric oxide production in endotoxic mice. J Immunol 156(4):1525–1530, 1996.  functioning African-American and white elders. Neurology 61(1):76–80, 2003.
                    273. O’Mahony L, Holland J, Jackson J, et al: Quantitative intracellular cytokine measure-    292. Abbatecola AM, Ferrucci L, Grella R, et al: Diverse effect of inflammatory markers
                     ment: Age-related changes in proinflammatory cytokine production. Clin Exp Immunol   on insulin resistance and insulin-resistance syndrome in the elderly. J Am Geriatr Soc
                     113(2):213–219, 1998.                                 52(3):399–404, 2004.
                    274. Roubenoff R, Harris TB, Abad LW, et al: Monocyte cytokine production in an elderly     293. Cesari M, Leeuwenburgh C, Lauretani F, et al: Frailty syndrome and skeletal muscle:
                     population: Effect of age and inflammation.  J Gerontol A Biol Sci Med Sci 53(1):   Results from the Invecchiare in Chianti study. Am J Clin Nutr 83(5):1142–1148, 2006.
                     M20–M26, 1998.                                       294. Pai JK, Pischon T, Ma J, et al: Inflammatory markers and the risk of coronary heart
                    275. Wu WC, Schifftner TL, Henderson WG, et al: Preoperative hematocrit levels and   disease in men and women. N Engl J Med 351(25):2599–2610, 2004.
                     postoperative outcomes in older patients undergoing noncardiac surgery.  JAMA     295. Shlipak MG, Fried LF, Crump C, et al: Elevations of inflammatory and procoagulant
                     297(22):2481–2488, 2007.                              biomarkers in elderly persons with renal insufficiency. Circulation 107(1):87–92, 2003.
                    276. Kollman C, Howe CW, Anasetti C, et al: Donor characteristics as risk factors in recip-    296. Ding C, Parameswaran V, Udayan R, et al: Circulating levels of inflammatory markers
                     ients after transplantation of bone marrow from unrelated donors: The effect of donor   predict change in bone mineral density and resorption in older adults: A longitudinal
                     age. Blood 98(7):2043–2051, 2001.                     study. J Clin Endocrinol Metab 93(5):1952–1958, 2008.
                    277. Penninx BW, Guralnik JM, Onder G, et al: Anemia and decline in physical performance     297. Spranger J, Kroke A, Mohlig M, et al: Inflammatory cytokines and the risk to develop
                     among older persons. Am J Med 115(2):104–110, 2003.   type 2 diabetes: Results of the prospective population-based European Prospective
                    278. Penninx BW, Kritchevsky SB, Newman AB, et al: Inflammatory markers and incident   Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 52(3):812–817,
                     mobility limitation in the elderly. J Am Geriatr Soc 52(7):1105–1113, 2004.  2003.
                    279. Penninx BW, Pahor M, Cesari M, et al: Anemia is associated with disability and     298. Finch CE, Landfield PW: Neuroendocrine and autonomic functions in aging mammals,
                     decreased physical performance and muscle strength in the elderly. J Am Geriatr Soc   in Handbook of the Biology of Aging, edited by CE Finch, EL Schenider, pp 567–595. Van
                     52(5):719–724, 2004.                                  Nostrand Reinhold, New York, 1985.
                    280. Penninx BW, Pluijm SM, Lips P, et al: Late-life anemia is associated with increased risk     299. Ferrucci L, Guralnik JM, Bandinelli S, et al: Unexplained anaemia in older persons is
                     of recurrent falls. J Am Geriatr Soc 53(12):2106–2111, 2005.  characterised by low erythropoietin and low levels of pro-inflammatory markers. Br J
                    281. Ezekowitz JA, McAlister FA, Armstrong PW: Anemia is common in heart failure and   Haematol 136(6):849–855, 2007.
                     is associated with poor outcomes: Insights from a cohort of 12 065 patients with new-     300. Denny SD, Kuchibhatla MN, Cohen HJ: Impact of anemia on mortality, cognition, and
                     onset heart failure. Circulation 107(2):223–225, 2003.  function in community-dwelling elderly. Am J Med 119(4):327–334, 2006.





































          Kaushansky_chapter 09_p0129-0142.indd   141                                                                   17/09/15   6:16 pm
   161   162   163   164   165   166   167   168   169   170   171