Page 163 - Williams Hematology ( PDFDrive )
P. 163
138 Part III: Epochal Hematology Chapter 9: Hematology in Older Persons 139
57. Longo DL: Telomere dynamics in aging: much ado about nothing? J Gerontol A Biol Sci 94. Partridge L: Some highlights of research on aging with invertebrates, 2010. Aging Cell
Med Sci 64(9):963-964, 2009. 10(1):5–9, 2011.
58. Bjorkstein J: Cross linkage and the aging process, in Theoretical Aspects of Aging, edited 95. Cristofalo VJ, Lorenzini A, Allen RG, et al: Replicative senescence: A critical review.
by M Rothstein, pp 43–56. Academic Press, New York, 1974. Mech Ageing Dev 2004;125(10–11):827–848, 2007.
59. Kohn RR: Principles of Mammalian Aging, 2nd ed. Prentice Hall, Englewood Cliffs, NJ, 96. Rohme D: Evidence for a relationship between longevity of mammalian species and life
1978. spans of normal fibroblasts in vitro and erythrocytes in vivo. Proc Natl Acad Sci U S A
60. Kreisle RA, Stebler BA, Ershler WB: Effect of host age on tumor-associated angiogene- 78(8):5009–5013, 1981.
sis in mice. J Natl Cancer Inst 82(1):44–47, 1990. 97. Schaffitzel E, Hertweck M: Recent aging research in Caenorhabditis elegans. Exp Ger-
61. Harman D: Aging: A theory based on free radical and radiation chemistry. J Gerontol ontol 41(6):557–563, 2006.
11(3):298–300, 1956. 98. D’Angelo MA, Raices M, Panowski SH, Hetzer MW: Age-dependent deterioration
62. Harman D: The aging process. Proc Natl Acad Sci U S A 78(11):7124–7128, 1981. of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell
63. Sohal RS, Svensson I, Sohal BH, Brunk UT: Superoxide anion radical production in 136(2):284–295, 2009.
different animal species. Mech Ageing Dev 49(2):129–135, 1989. 99. Ohlstein B, Spradling A: The adult Drosophila posterior midgut is maintained by
64. Sohal RS, Sohal BH, Brunk UT: Relationship between antioxidant defenses and longev- pluripotent stem cells. Nature 439(7075):470–474, 2006.
ity in different mammalian species. Mech Ageing Dev 53(3):217–227, 1990. 100. Marianes A, Spradling AC. Physiological and stem cell compartmentalization within
65. Sohal RS, Weindruch R: Oxidative stress, caloric restriction, and aging. Science the Drosophila midgut. Elife 2:e00886, 2013.
273(5271):59–63, 1996. 101. Sun Y, Yolitz J, Wang C, et al: Aging studies in Drosophila melanogaster. Methods Mol
66. Perez VI, Van Remmen H, Bokov A, et al: The overexpression of major antioxidant Biol 1048:77–93, 2013.
enzymes does not extend the lifespan of mice. Aging Cell 8(1):73–75, 2009. 102. Campisi J: Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol
67. Lee CM, Chung SS, Kaczkowski JM, et al: Multiple mitochondrial DNA deletions asso- 11(11):S27–S31, 2001.
ciated with age in skeletal muscle of rhesus monkeys. J Gerontol 48(6):B201–B205, 1993. 103. Green DR, Evan GI: A matter of life and death. Cancer Cell 1(1):19–30, 2002.
68. Melov S, Shoffner JM, Kaufman A, Wallace DC: Marked increase in the number and 104. Campisi J. Cellular senescence and apoptosis: How cellular responses might influence
variety of mitochondrial DNA rearrangements in aging human skeletal muscle. Nucleic aging phenotypes. Exp Gerontol 2003;38(1–2):5–11, 2001.
Acids Res 23(20):4122–4126, 1995. 105. Hasty P, Campisi J, Hoeijmakers J, et al: Aging and genome maintenance: Lessons from
69. Schwarze SR, Lee CM, Chung SS, et al: High levels of mitochondrial DNA deletions in the mouse? Science 299(5611):1355–1359, 2003.
skeletal muscle of old rhesus monkeys. Mech Ageing Dev 83(2):91–101, 1995. 106. Samper E, Nicholls DG, Melov S: Mitochondrial oxidative stress causes chromosomal
70. Li Y, Huang TT, Carlson EJ, et al: Dilated cardiomyopathy and neonatal lethality in instability of mouse embryonic fibroblasts. Aging Cell 2(5):277–285, 2003.
mutant mice lacking manganese superoxide dismutase. Nat Genet 11(4):376–381, 1995. 107. Bandyopadhyay D, Medrano EE: The emerging role of epigenetics in cellular and
71. Epstein CJ, Avraham KB, Lovett M, et al: Transgenic mice with increased Cu/Zn-super- organismal aging. Exp Gerontol 38(11–12):1299–1307, 2003.
oxide dismutase activity: Animal model of dosage effects in Down syndrome. Proc Natl 108. Narita M, Lowe SW: Executing cell senescence. Cell Cycle 3(3):244–246, 2004.
Acad Sci U S A 84(22):8044–8048, 1987. 109. Neumeister P, Albanese C, Balent B, et al: Senescence and epigenetic dysregulation in
72. Harris TB, Kiel D, Roubenoff R, et al: Association of insulin-like growth factor-I with cancer. Int J Biochem Cell Biol 34(11):1475–1490, 2002.
body composition, weight history, and past health behaviors in the very old: The 110. Bringold F, Serrano M: Tumor suppressors and oncogenes in cellular senescence. Exp
Framingham Heart Study. J Am Geriatr Soc 45(2):133–139, 1997. Gerontol 35(3):317–329, 2000.
73. Birkenhager-Gillesse EG, Derksen J, Lagaay AM: Dehydroepiandrosterone sulphate 111. Lundberg AS, Hahn WC, Gupta P, Weinberg RA: Genes involved in senescence and
(DHEAS) in the oldest old, aged 85 and over. Ann N Y Acad Sci 719:543–552, 1994. immortalization. Curr Opin Cell Biol 12(6):705–709, 2000.
74. Rudman D, Drinka PJ, Wilson CR, et al: Relations of endogenous anabolic hormones 112. Itahana K, Dimri G, Campisi J: Regulation of cellular senescence by p53. Eur J Biochem
and physical activity to bone mineral density and lean body mass in elderly men. Clin 268(10):2784–2791, 2001.
Endocrinol (Oxf) 40(5):653–661, 1994. 113. Serrano M, Lin AW, McCurrach ME, et al: Oncogenic ras provokes premature cell
75. Hobbs CJ, Plymate SR, Rosen CJ, Adler RA: Testosterone administration increases senescence associated with accumulation of p53 and p16INK4a. Cell 88(5):593–602,
insulin-like growth factor-I levels in normal men. J Clin Endocrinol Metab 77(3): 1997.
776–779, 1993. 114. Ferbeyre G, de Stanchina E, Querido E, et al: PML is induced by oncogenic ras and
76. Rudman D, Feller AG, Nagraj HS, et al: Effects of human growth hormone in men over promotes premature senescence. Genes Dev 14(16):2015–2027, 2000.
60 years old. N Engl J Med 323(1):1–6, 1990. 115. Pearson M, Carbone R, Sebastiani C, et al: PML regulates p53 acetylation and prema-
77. Walford R: The Immunological Theory of Aging. Williams and Wilkins, Baltimore, 1969. ture senescence induced by oncogenic Ras. Nature 406(6792):207–210, 2000.
78. Makinodan T, Kay MM: Age influence on the immune system. Adv Immunol 29: 116. Rossi D, Cerri M, Capello D, et al: Biological and clinical risk factors of chronic
287–330, 1980. lymphocytic leukaemia transformation to Richter syndrome. Br J Haematol 142(2):
79. Smith GS, Walford RL: Influence of the main histocompatibility complex on ageing in 202–215, 2008.
mice. Nature 270(5639):727–729, 1977. 117. Miura T, Mattson MP, Rao MS: Cellular lifespan and senescence signaling in embryonic
80. Hirokawa K: Understanding the mechanism of the age-related decline in immune func- stem cells. Aging Cell 3(6):333–343, 2004.
tion. Nutr Rev 50(12):361–366, 1992. 118. Odorico JS, Kaufman DS, Thomson JA: Multilineage differentiation from human
81. Christensen K, Vaupel JW: Determinants of longevity: Genetic, environmental and embryonic stem cell lines. Stem Cells 19(3):193–204, 2001.
medical factors. J Intern Med 240(6):333–341, 1996. 119. Chen J: Senescence and functional failure in hematopoietic stem cells. Exp Hematol
82. Population Division, Department of Economic and Social Affairs, United Nations: 32(11):1025–1032, 2004.
World Population Prospects: The 2006 Revision. http://www.un.org/esa/population/ 120. Geiger H, Van Zant G: The aging of lympho-hematopoietic stem cells. Nat Immunol
ordering.htm. 3(4):329–333, 2002.
83. Orr WC, Sohal RS: Extension of life-span by overexpression of superoxide dismutase 121. Park IK, Morrison SJ, Clarke MF: Bmi1, stem cells, and senescence regulation. J Clin
and catalase in Drosophila melanogaster. Science 263(5150):1128–1130, 1994. Invest 113(2):175–179, 2004.
84. Anderson RM, Shanmuganayagam D, Weindruch R: Caloric restriction and aging: 122. Villa A, Navarro-Galve B, Bueno C, et al: Long-term molecular and cellular stability of
Studies in mice and monkeys. Toxicol Pathol 37(1):47–51, 2009. human neural stem cell lines. Exp Cell Res 294(2):559–570, 2004.
85. Mattson MP. Dietary factors, hormesis and health. Ageing Res Rev 7(1):43–48, 2008. 123. Boulanger CA, Smith GH: Reducing mammary cancer risk through premature stem
86. Ramsey JJ, Colman RJ, Binkley NC, et al: Dietary restriction and aging in rhesus mon- cell senescence. Oncogene 20(18):2264–2272, 2001.
keys: The University of Wisconsin study. Exp Gerontol 35(9–10):1131–1149, 2000. 124. Serakinci N, Guldberg P, Burns JS, et al: Adult human mesenchymal stem cell as a target
87. Lane MA, Roth GS, Ingram DK: Caloric restriction mimetics: A novel approach for for neoplastic transformation. Oncogene 23(29):5095–5098, 2004.
biogerontology. Methods Mol Biol 371:143–149, 2007. 125. Lichtman MA, Rowe JM: The relationship of patient age to the pathobiology of the
88. Heilbronn LK, de Jonge L, Frisard MI, et al: Effect of 6-month calorie restriction on clonal myeloid diseases. Semin Oncol 31(2):185–197, 2004.
biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight indi- 126. Artz AS, Fergusson D, Drinka PJ, et al: Prevalence of anemia in skilled-nursing home
viduals: A randomized controlled trial. JAMA 295(13):1539–1548, 2006. residents. Arch Gerontol Geriatr 39(3):201–206, 2004.
89. Redman LM, Martin CK, Williamson DA, Ravussin E. Effect of caloric restriction in 127. Guralnik JM, Eisenstaedt RS, Ferrucci L, et al: Prevalence of anemia in persons 65 years
non-obese humans on physiological, psychological and behavioral outcomes. Physiol and older in the United States: Evidence for a high rate of unexplained anemia. Blood
Behav 94(5):643–648, 2008. 104(8):2263–2268, 2004.
90. Fowler CG, Chiasson KB, Hart DB, et al: Tympanometry in rhesus monkeys: Effects of 128. Joosten E, Pelemans W, Hiele M, et al: Prevalence and causes of anaemia in a geriatric
aging and caloric restriction. Int J Audiol 47(4):209–214, 2008. hospitalized population. Gerontology 38(1–2):111–117, 1992.
91. Raman A, Ramsey JJ, Kemnitz JW, et al: Influences of calorie restriction and age 129. Cesari M, Penninx BW, Lauretani F, et al: Hemoglobin levels and skeletal muscle:
on energy expenditure in the rhesus monkey. Am J Physiol Endocrinol Metab Results from the InCHIANTI study. J Gerontol A Biol Sci Med Sci 59(3):249–254, 2004.
292(1):E101–E106, 2007. 130. Cesari M, Penninx BW, Pahor M, et al: Inflammatory markers and physical performance
92. Hayflick L: The limited in vitro lifetime of human diploid cell strains. Exp Cell Res in older persons: The InCHIANTI study. J Gerontol A Biol Sci Med Sci 59(3):242–248,
37:614–636, 1965. 2004.
93. Partridge L: The new biology of ageing. Philos Trans R Soc Lond B Biol Sci 365(1537): 131. Hakim FT, Gress RE: Immunosenescence: Deficits in adaptive immunity in the elderly.
147–154, 2010. Tissue Antigens 70(3):179–189, 2007.
Kaushansky_chapter 09_p0129-0142.indd 138 17/09/15 6:16 pm

