Page 2374 - Williams Hematology ( PDFDrive )

2346
Gy(a–) (Do null ) found in eastern Europeans and
In: located on CD44 adhesion protein
Ge: located on glycophorins C and D
Hy– and Jo(a–): found only in blacks
Japanese
>99.9
<0.1
96
–
–
>99.9
<0.1
>99
>99
99
Implicated in Antigen Frequency (%) Comments Blacks Whites HDFN – >99 +DAT Part XIII: Transfusion Medicine Knops antigens associated with CR1 (com- 99 98 No plement) receptor, clinically insignificant antibodies 94 98 No 98 92 No Sc1: some antibodies react in serum but not – >99.9 +DAT plasma – 1 +DAT – >99.9 Mild JMH: carrier protein CDw108 >99.9 >99.9 No Chapter 136: Erythrocyte Antigens and Antibodies 2347
(+DAT)
(+DAT)
(+DAT)
+DAT
No
HTR No – Mod No– Mod- erate No– Mod No– Mod Yes No – Sev No No No No No No– Mild No
Summary of Selected Antierythrocyte Antibodies (Continued )
Activates Complement No No No Yes No No No No No Yes No No No
Serologic Activity 37°C ENZ/DTT AHG nc(I)/D(V) Most nc(I)/D(V) Most nc(I)/D(V) Most D/nc Most D/D Most D/D Most D/D/V Most D/D Most D/D Most nc/nc Most nc/-V Most nc(I)/nc Most D/D Most

RT – – – – – – – – – – – – – D, destroyed; DTT, dithiothreitol; ENZ, enzyme (papain/ficin); I, increased; nc, no change; V, variable.

Ig Class IgG Most Most Most Most Most Most Most Most Most Most Most Most Most

IgM – – – – – – – – – – – –

TABLE 136–5. Blood Antibody Group Hy Gy a Jo a General Gerbich group In a Indian In b Kn a Knops McC a Yk a Sc1 Scianna Sc2 Sc3 JMH JMH

Kaushansky_chapter 136_p2327-2352.indd 2346 9/21/15 4:31 PM