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2346 Part XIII: Transfusion Medicine Chapter 136: Erythrocyte Antigens and Antibodies 2347

Gy(a–) (Do null ) found in eastern Europeans and
Sc1: some antibodies react in serum but not
Knops antigens associated with CR1 (com-
plement) receptor, clinically insignificant
In: located on CD44 adhesion protein
Ge: located on glycophorins C and D
Hy– and Jo(a–): found only in blacks

JMH: carrier protein CDw108

Comments Japanese antibodies plasma

Antigen Frequency (%) Blacks Whites – >99 – >99 – >99 >99.9 >99.9 <0.1 <0.1 96 99 99 98 94 98 98 92 – >99.9 – 1 – >99.9 >99.9 >99.9

Implicated in HDFN +DAT +DAT No (+DAT) (+DAT) (+DAT) No No No +DAT +DAT Mild No

HTR No – Mod No– Mod- erate No– Mod No– Mod Yes No – Sev No No No No No No– Mild No
Summary of Selected Antierythrocyte Antibodies (Continued )

Activates Complement No No No Yes No No No No No Yes No No No

Serologic Activity 37°C ENZ/DTT AHG nc(I)/D(V) Most nc(I)/D(V) Most nc(I)/D(V) Most D/nc Most D/D Most D/D Most D/D/V Most D/D Most D/D Most nc/nc Most nc/-V Most nc(I)/nc Most D/D Most

RT – – – – – – – – – – – – – D, destroyed; DTT, dithiothreitol; ENZ, enzyme (papain/ficin); I, increased; nc, no change; V, variable.

Ig Class IgG Most Most Most Most Most Most Most Most Most Most Most Most Most

IgM – – – – – – – – – – – –

TABLE 136–5. Blood Antibody Group Hy Gy a Jo a General Gerbich group In a Indian In b Kn a Knops McC a Yk a Sc1 Scianna Sc2 Sc3 JMH JMH

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