Page 2370 - Williams Hematology ( PDFDrive )

2344
Autoantibodies commonly directed against
autoantibody, but strong alloantibody in O h
All alloantibodies: clinically significant
D: most common immune antibody
A1: usually not clinically significant
E/C or E/c: often found together
C: often found with D
H: usually weak
—
92
97
99
33
21
—
20
>99.9
85
70
98
80
30
11
30
Mild to
Mild to
Mild to
Implicated in Antigen Frequency (%) Comments Blacks Whites HDFN A/B: very clinically significant, sometimes IgA 27 40 Mild Part XIII: Transfusion Medicine Rh protein — 64 Mild — 1 Mild to Mod 30 <1 No Common in pregnancy 23 22 No Not clinically significant; Le(a–b–) individuals 55 72 No commonly make anti-Le a but can simultane- ously make anti-Le a and anti-Le b I: common autoantibody, rare significant >99.9 >99.9 No alloantibody i: rare autoantibody 100 100 Rare (mild) P1: usually not clinically significant 94 79 No P: Donath-Landsteiner antibody in PCH >99.9 >99.9 No–Mi
Mild
Mild
Mild
Sev
Sev
Sev
No
—
HTR Yes Yes Rare Rare Yes Yes Yes Yes Yes Yes Yes Yes Rare No Rare No Rare Yes Yes Rare Rare Yes Yes Yes
Summary of Selected Erythrocyte Antibodies (Continued )
Activates Complement Yes Yes Rare Rare No No No No No No No No Yes Yes Yes Yes Few Yes Yes No No Some Rare Rare
Serologic Activity 37°C ENZ/DTT AHG I/nc Most I/nc Most I/nc Rare I/nc Rare I/nc Most I/nc Most I/nc Most I/nc Most I/nc Most I/nc Most I/nc Most I/nc Most I/nc Some I/nc Some I/nc Some I/nc Some I/nc Some I/nc Some I/nc Some D/nc Few D/nc Rare V/nc Most V/nc Most nc/nc Most
RT Most Most Most Most Some — Some — — — — — Most Most Most Most Most Most Most Most Most Some Few —
Ig Class IgG Some Some Rare Rare Most Most Most Most Most Most Most Most Rare Rare — — Rare Few Few Some Some Some Most Most
IgM Most Most Most Most Some Few Some — — — Some — Most Most Most Most Most Most Most Some Some Some Few —

TABLE 136–5. Blood Antibody Group A ABO B A1 H D Rh C E c e f (ce) C W VS/V Le a Lewis Le b I Ii i P1 P1PK P GLOB PP1P k M MNSs N S s U

Kaushansky_chapter 136_p2327-2352.indd 2344 9/21/15 4:31 PM