Page 2371 - Williams Hematology ( PDFDrive )

2344 Part XIII: Transfusion Medicine Chapter 136: Erythrocyte Antigens and Antibodies 2345

(continued )
A/B: very clinically significant, sometimes IgA

A1: usually not clinically significant autoantibody, but strong alloantibody in O h D: most common immune antibody E/C or E/c: often found together All alloantibodies: clinically significant Autoantibodies commonly directed against Not clinically significant; Le(a–b–) individuals commonly make anti-Le a but can simultane- ously make anti-Le a and anti-Le b I: common autoantibody, rare significant P1: usually not clinically significant P: Donath-Landsteiner antibody in PCH M: common, usually not clinically significant N: rare, usually not clinically significant SsU: clinically significant a

Comments H: usually weak C: often found with D Rh protein Common in pregnancy alloantibody i: rare autoantibody ficities reported

Antigen Frequency (%) Blacks Whites 27 40 20 11 — 30 — >99.9 92 85 33 70 21 30 97 80 99 98 — 64 — 1 30 <1 23 22 55 72 >99.9 >99.9 100 100 94 79 >99.9 >99.9 >99.9 >99.9 70 78 74 72 31 55 97 89 99.7 100

Implicated in HDFN Mild Mild No — Mild to Sev Mild to Sev Mild Mild to Sev Mild Mild Mild to Mod No No No No Rare (mild) No No–Mild No –Sev Rare (Rare) Mild – Sev No – Sev Mild–Sev

HTR Yes Yes Rare Rare Yes Yes Yes Yes Yes Yes Yes Yes Rare No Rare No Rare Yes Yes Rare Rare Yes Yes Yes

Summary of Selected Erythrocyte Antibodies (Continued )
Activates Complement Yes Yes Rare Rare No No No No No No No No Yes Yes Yes Yes Few Yes Yes No No Some Rare Rare

Serologic Activity 37°C ENZ/DTT AHG I/nc Most I/nc Most I/nc Rare I/nc Rare I/nc Most I/nc Most I/nc Most I/nc Most I/nc Most I/nc Most I/nc Most I/nc Most I/nc Some I/nc Some I/nc Some I/nc Some I/nc Some I/nc Some I/nc Some D/nc Few D/nc Rare V/nc Most V/nc Most nc/nc Most

RT Most Most Most Most Some — Some — — — — — Most Most Most Most Most Most Most Most Most Some Few —

Ig Class IgG Some Some Rare Rare Most Most Most Most Most Most Most Most Rare Rare — — Rare Few Few Some Some Some Most Most

IgM Most Most Most Most Some Few Some — — — Some — Most Most Most Most Most Most Most Some Some Some Few —

TABLE 136–5. Blood Antibody Group A ABO B A1 H D Rh C E c e f (ce) C W VS/V Le a Lewis Le b I Ii i P1 P1PK P GLOB PP1P k M MNSs N S s U

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