Page 2492 - Williams Hematology ( PDFDrive )

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2462 Index Index 2463

specimen preparation for, 27–28 Mature neutrophil reserve, 941, 941t MDR protein-1, 1404
in storage diseases, 33 Mature T-cell lymphomas MDSs. See Myelodysplastic syndromes
in T-cell large granular lymphocytic cutaneous. See Cutaneous T-cell (MDSs)
leukemia, 1565, 1565f lymphoma (CTCL) Mean cell hemoglobin (MCH), 14
in transient aplastic crisis, 541f systemic. See Peripheral T-cell lymphoma Mean cell hemoglobin concentration
in Waldenström macroglobulinemia, (PTCL) (MCHC), 14, 766
1786f, 1788t, 1791, 1792f MAVS (mitochondrial antiviral signaling Mean cell volume (MCV), 14, 18t, 19f, 21
MART-1, 412 protein), 302, 302f, 303 Mean corpuscular hemoglobin concentration
Masked Ph chromosome, 1447 MAX, 234t (MCHC)
Masked translocation, 1447 May-Hegglin disease/anomaly, 22f, 23, 2061 in hereditary spherocytosis, 675
Massively parallel digital sequencing. m-BACOD regimen, for diffuse large B-cell iron deficiency and, 634f
See Next-generation sequencing lymphoma, 1629–1630 Mean corpuscular volume (MCV), 634f
Massive transfusion, 2385 m-bcr breakpoints, 1443, 1449 Mean platelet volume (MPV), 17
Mast cell activation syndrome (MCAS), 978 M-bcr breakpoints, 1442 Mean red cell volume (MCV), 102
Mast cell growth factor. See Stem cell factor MBL (mannose-binding lectin), 1017 Measles
(SCF) MBL (monoclonal B-cell lymphocytosis), lymphocytopenia and, 1204
Mast cell knockin mice, 970 1199–1200, 1201t, 1542–1543 purpura and, 2104
Mast cell leukemia, 978 MBL (mannan-binding lectin) pathway, 289f, Mechlorethamine. See Nitrogen mustard
Mast cell nevi, 973 290 Meckel diverticulum, blood loss and, 629
Mast cells MBP (major basic protein), 929, 948, 952 Mediastinal germ cell tumors, 1386–1387
in asthma, 969 MCAS (mast cell activation syndrome), 978 Mediators
basophils and, 967–968 MCFD2/MCFD2, 2135t, 2139 basophil, 967t, 968
in chronic inflammation, 291 MCH (mean cell hemoglobin), 14 lipid, eosinophils and release of, 952
disorders MCHC (mean cell hemoglobin mast cells, 967t, 968
mast cell activation syndrome, 978 concentration), 14, 766 MEF2B, 235t, 236t, 1627t, 1644
mast cell leukemia, 978 MCL. See Mantle cell lymphoma (MCL) MEFV, 1025
mast cell nevi, 978 MCL-1, 1528, 1711 Megakaryoblasts, 1815–1817, 1816f
mast cell sarcoma, 978 MCL-1 (MCL1), 210, 1736 Megakaryocyte-erythroid progenitor (MEP)
monoclonal mast cell activation Mcl-1 protein, 206, 216, 218, 231t, 237 cells, 259, 268
syndrome, 977–978 McLeod phenotype/syndrome, 681, 2341t, Megakaryocytes
systemic mastocytosis. See Systemic 2342 marrow, 32t, 35
mastocytosis MCP, 2260, 2259t in myelodysplastic syndromes, 1350f, 1354
distinguishing features, 966, 966f MCP-1 (monocyte chemoattractant release, 72, 73f
heterogeneity, 966–967 protein). See CCL2 (monocyte Megakaryopoiesis, 64–65, 1815–1824
in host defense, 969–970 chemoattractant protein, MCP-1) extrinsic regulation, 1821–1823
in IgE-associated immune response, 969 MCP regimen maturation stages, 1816t
marrow, 35 for follicular lymphoma, 1646t precursor cell kinetics, 75t
mediators, 967t, 968 for mantle cell lymphoma, 1657t progenitors, 271
natural history, 967t M-CSF (macrophage colony-stimulating stage I (megakaryoblasts), 1815–1817,
normal levels, 972 factor), 62t, 249, 1077–1078, 1077f 1816f
secondary changes in numbers of, M-CSF (monocyte colony-stimulating stage II, 1817–1818
972–973, 972t factor), 264t, 1352 stage III/IV, 1818–1820, 1819f, 1820f
structure, 931f, 932, 968 MCSs (multispecies conserved sequences), Megaloblastic anemias, 593–608
surface membrane structures, 967t 730 acute, 604–605
in Waldenström macroglobulinemia, 1788, MCV (mean cell volume), 14, 18t, 19f, 21 autosomal recessive, 605
1791, 1792f MCV (mean corpuscular volume), 634f clinical features, 594
Mast cell sarcoma, 978 MCV (mean red cell volume), 102 definition, 593
Mastocytomas, 973 MCyR (major cytogenic response), 1452t etiology and pathogenesis, 584, 593–594,
Mastocytosis, 973. See also Systemic mCyR (minor cytogenic response), 1452t 596t
mastocytosis MD2, 1054 acute erythroid leukemia and, 608
Matriptase 2 (Tmprss6), 621, 621t MDA5 (melanoma differentiation-associated in childhood, 605, 607
Matrix metalloproteinases (MMPs), 1014, gene 5), 300–301, 302f cobalamin deficiency, 583, 590. See also
1874, 1881, 2307, 2311 MDM2 (murine double minute protein 2), Cobalamin deficiency
Matrix modulators, 2284f 238 congenital dyserythropoietic anemia,
Matrix proteins, 266–267. See also specific MDP (muramyl dipeptide), 299, 301f 608
types MDR, 341 drug-related, 596t, 605, 606t

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