Page 2497 - Williams Hematology ( PDFDrive )

2468 Index Index 2469

Mycobacterial infections maturation, 926f, 940–941, 940f, 941t Myeloid differentiation primary response 88
chronic inflammation and, 290, 291 structure, 925 (MyD88), 297f, 298
evasion of phagocytic mechanisms in, Myelocytes Myeloid leukemia hybrid, 1386
1062, 1064f marrow, 32t, 34 Myeloid-lymphoid leukemias, 1386
in HIV infection, 1097, 1240, 1241t maturation, 940–941, 940f, 941t Myeloid–natural killer cell hybrid leukemia,
in idiopathic CD4+ lymphocytopenia, neutrophilic, 925, 927f 1386
1206 Myelodysplasia Myeloid progenitors, 270–271
after hematopoietic cell transplantation, α-thalassemia and, 739 Myeloid (granulocytic) sarcoma
369 aplastic anemia and, 520 in acute myelogenous leukemia, 1285,
in immunocompromised host, 384 definition, 1277–1278, 1343 1381
Mendelian susceptibility to, 1231 gene mutations, 1308t in chronic myelogenous leukemia, 1465
monocytosis in, 1097 Myelodysplastic syndromes (MDSs) nonleukemic, 1398
treatment, 386 acute myelogenous leukemia and, 178, 180, Myeloid series, marrow, 34
Mycophenolate mofetil 1341–1342 Myeloid-to-erythroid (M:E) ratio, marrow, 31
for autoimmune hemolytic anemia, 839 acute promyelocytic leukemia and, 1406 Myelokathexis, 994, 1226
in reduced-intensity conditioning, 360 vs. aplastic anemia, 520 Myeloma
Mycophenolic acid, 200 classification, 1343–1344, 1343t chronic lymphocytic leukemia and, 1541
Mycoplasma pneumoniae clinical features, 1352–1353, 2081–2082 clinical features, 1740t, 1741f
autoimmune hemolytic anemia and, 824, definition, 1341–1342 cast nephropathy, 428, 430t, 1744
828 diagnostic criteria, 1354, 1355t extramedullary disease, 1746
hemolytic anemia and, 820 epidemiology, 1344–1345, 1344f hematologic abnormalities, 1740–1741
Mycosis fungoides (MF). See also Cutaneous etiology, 1345 hypercalcemia, 1744
T-cell lymphoma (CTCL) history, 1342–1343 hyperviscosity, 1746
classification, 1680t laboratory features infections, 1745–1746
clinical features, 1680, 1681f blood, 1350f, 1353 neuropathy, 1746
definition and history, 1679 marrow, 37, 1350f, 1353–1354 pain, 1745
differential diagnosis, 1683–1684 plasma, 1353 plasma cell leukemia, 1746. See also
epidemiology, 1679 monocytosis in, 1096 Plasma cell leukemia
erythrodermic subset, 1683, 1684t paroxysmal nocturnal hemoglobinuria platelet dysfunction, 2082
etiology and pathogenesis, 1680 and, 576t, 578 renal disease, 1744–1745
gene mutations, 1498t pathogenesis, 1345–1352 spinal cord compression, 1746–1747
laboratory features, 1498t, 1680–1682, chromosomal abnormalities, 178, 180t, definition and history, 1733
1681f, 1682f, 1683f 182, 221t, 1346–1348, 1346t differential diagnosis, 1726, 1726t, 1750
prognosis, 1688 epigenetic regulators, 1349–1352 epidemiology, 1734
staging, 1682–1683, 1682t, 1683f, 1683t gene mutations, 180t, 181t, 227–228t, essential monoclonal gammopathy and,
treatment, 1684–1688 233–234t, 1346t, 1348–1349 1722, 1734, 1734f
guidelines/algorithm, 1684–1685, microenvironmental changes, 1352 etiology and pathogenesis, 1709
1685f prognosis, 1355–1356, 1355t, 1356t bone metabolism, 1713, 1737–1738,
skin-directed, 429t, 433, 1684t, sideroblastic anemia and, 918–919 1739f
1685–1686 therapy-related, 182, 182f, 1354 cell growth and metabolism, 200–201
systemic, 1684t, 1686–1688 treatment, 1356–1362 chromosomal abnormalities, 185t, 188
MYD88, 231t, 234t, 235t, 1529, 1644, 1712 demethylating agents, 239, 336 1q/1p, 188, 223t, 1759
MyD88 (myeloid differentiation factor/ in higher-risk disease, 1360–1362 deletions, 185t, 1736, 1736t, 1744,
protein 88), 1054, 1084, 1230 in lower-risk disease, 1357–1360 1744f, 1745f, 1759
MyD88 (myeloid differentiation primary prognostic score and, 1356–1357 detection methods, 1711
response 88), 297f, 298 Myelodysplastic transformation, in hyperdiploidy, 185t, 224t, 1735, 1736t
MyD88 adapter-like (MAL), 297f, 298 polycythemia vera, 1295 karyotype abnormalities, 1735f, 1745f
MYD88L265, 1711, 1722 Myelofibrosis prognosis and, 1759–1760
MYD88 L265P , 1786–1787, 1787f, 1788, 1791 primary. See Primary myelofibrosis (PMF) translocations, 185t, 188, 224t, 225,
Myelin-associated glycoprotein (MAG), 1790 secondary, 1325 1735–1736, 1735f, 1736t, 1744,
Myeloblastoma. See Myeloid (granulocytic) Myelofibrotic transformation, in 1744f
sarcoma thrombocythemia, 1309 endogenous factors, 1709
Myeloblasts Myelogene, 1373, 1438 exogenous factors, 1709, 1734
in acute myelogenous leukemia, 1381 Myeloid dendritic cells, markers, 1080t gene expression, 1711
acute myelogenous leukemia and, 1375 Myeloid differentiation factor/protein 88 gene mutations, 166, 170, 188, 233–234t
marrow, 32t, 34, 927f (MyD88), 1054, 1084, 1230 BRAF, 233t, 1737

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