Page 2499 - Williams Hematology ( PDFDrive )

2470 Index Index 2471

Natural killer (NK) cell lymphocytosis, Neck, history of disorders of, 5 in iron deficiency, 632
1202–1203 Necrosis, marrow, 33 in Langerhans cell histiocytosis, 1105,
Natural killer (NK) cell lymphoproliferation, Necrotic lesions, history of, 6 1105f, 1106, 1107
1265 Neisseria meningitidis, 868, 869, 1017, 2104, macrophages and, 1083
Natural killer (NK) cell neoplasms. See also 2340 in myeloma, 1746, 1757
specific types NEK2, 1711, 1712 red cell transfusion in, 2371
leukemia, 1192, 1499t, 1563, 1566 Nelarabine, 323f, 325, 1518 in sickle cell disease, 769–770
lymphoma/lymphoproliferative disorders Nematode anticoagulant protein c2 (NAPc2), in thrombotic thrombocytopenic purpura,
chromosomal abnormalities, 185t 2214 2254
extranodal, 1192, 1498t NEMO (NF-κB essential modulator), 298, in Waldenström macroglobulinemia,
histologic subtypes and frequency of, 1214t, 1215 1789–1790, 1791
1572t NEM-sensitive fusion protein (NSF), 1016 Neurologic examination, 4–5, 9
Natural killer (NK) cell progenitors, 270 Neocytolysis, 498, 810–811 Neuronal cell-adhesion molecule (NCAM,
Natural killer (NK) cell receptors, 1190–1191, Neogenin, 621t CD56), 1142, 1189, 1699, 1726,
1190f, 1192 Neomycin, megaloblastic anemia and, 606t 1737
Natural killer (NK) cells Neonates/neonatal disease. See Newborns/ Neuroreticular complex, 56
antigens, 1142, 1142t infants Neutropenia, 991–997
in cancer treatment, 1192–1193 Neoplastic megakaryocytopoiesis, 1321 chronic idiopathic, 983, 985, 995
in chronic myelogenous leukemia, 1440 Neoplastic myeloid disorders. See Clonal classification, 41, 983, 984t
cytoplasmic granules in, 1145 myeloid disorders clinical approach to, 997
definition, 1189 Netosis, 1017 clinical features, 985
dendritic cells and, 307 NETs (neutrophil extracellular traps), 1007f, congenital, 992–993, 993f
development, 1151 1017, 1856 consultative approach to, 41–42
disorders, 1197. See also Chronic Neulasta, for diffuse large B-cell lymphoma, cyclic, 983, 985, 994, 1097
lymphoproliferative disorders of 1629t definition, 985, 991
NK cells (CLPD-NK); Natural Neural stem cells (NSCs), 451 etiology, 984t, 985
killer (NK) cell neoplasms Neural tube defects, 598 autoimmune, 995, 996f
functions, 1190–1191 Neuroacanthocytosis, 681 disorders affecting neutrophil utilization
cell-mediated cytotoxicity, 1190–1191, abetalipoproteinemia, 681 and turnover, 995–996
1190f chorea-acanthocytosis syndrome, 681 disorders of production, 992–995
cytokine production, 1191 differential diagnosis, 682 drug-induced, 985, 992, 996–997, 998t
in lymph nodes, 93 HARP syndrome, 682 “ethnic,” 985
morphology, 1142, 1189 Huntington disease-like 2 disorder, 682 in HIV infection, 997, 1254
in mycosis fungoides, 1680 McLeod syndrome, 681 infectious, 997
origin and tissue distribution, 1189 pantothenate kinase-associated hematopoietic cell transplantation and, 369
pathologic alterations in numbers of, 1192 neurodegeneration, 682 pathophysiologic mechanisms, 991–992,
physiologic roles Neuroendocrine theory of aging, 131 992f
innate resistance, 1191, 1191f Neurologic disease/symptoms. See also pseudo-, 985
modulation of hematopoiesis, Central nervous system severity of, infection risk and, 383
1191–1192 in acute lymphoblastic leukemia relapse, Neutropenic enterocolitis, 1410
regulation of adaptive immunity, 1191 1517, 1518 Neutrophil actin dysfunction, 1024
Natural killer (NK)/T-cell lymphoma, 1581, in acute myelogenous leukemia, 1381, Neutrophil-activating peptide-1. See
1694t, 1695t. See also Extranodal 1397–1398 Interleukin (IL)-8
natural killer (NK)/T-cell in AL amyloidosis, 1760, 1775, 1775t, 1779 Neutrophil-activating peptide-2, 288t
lymphoma, nasal type in antiphospholipid syndrome, 2238–2239 Neutrophil alkaline phosphatase activity
NB1 glycoprotein, 2358 brain injury, multipotential cell therapy in chronic myelogenous leukemia, 1445
NBEAL2, 1850, 1853 for, 451–452 in myelodysplastic syndromes, 1353
NBT (nitroblue tetrazolium), in newborn, brain tumors, erythrocytosis and, 879 in primary myelofibrosis, 1326
107 in cobalamin deficiency, 602, 602f Neutrophil antigens. See Human neutrophil
NCAM (neuronal cell-adhesion molecule, in disseminated intravascular coagulation, antigens (HNAs)
CD56), 1142, 1189, 1699, 1726, 2204, 2208 Neutrophil collagenase, 1012t, 1014, 1322
1737 in Erdheim-Chester disease, 1111 Neutrophil extracellular traps (NETs), 1007f,
NCF1 (p47 phox ), 1028t, 1029 in essential monoclonal gammopathy, 1724 1017, 1856, 1941, 1941f
NCF2 (p67 phox ), 1028t, 1029 in Gaucher disease, 1125 Neutrophil gelatinase-associated lipocalin
NCF4 (p40 phox ), 1029 in hemolytic uremic syndrome, 2259 (NGAL), 1009, 1012t, 1013–1014
Necator americanus, 949 in hemophilia, 2119–2120 Neutrophilia, 997–1001

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