Page 1223 - Clinical Immunology_ Principles and Practice ( PDFDrive )

1186 PART TEN Prevention and Therapy of Immunological Diseases

Antigen-presenting cell

CD80
MHC

TCR
CD28

CD3 PIP 3 ITK Ras RasGAP Ras PIP 3
Ick GTP GTP
fyn LAT PDK1
P Grb2 Sos RasGAP p110 p85
P SLP-76 GADS P
PLCγ1 P P
P P P P13’K
P
DaG
P
P ZAP-70 P IP 3
P’tn
PKC Raf PKB
T cell
Downstream serine/threonine
kinases and their effectors
FIG 88.1 The Proximal Signaling Events in Response to T-Cell Receptor (TCR) Activation
by an Antigen-Presenting Cell. Tyrosine and lipid kinases are indicated in red, and serine/ threonine
kinases are indicated in blue.

TABLE 88.1 Functions and Signaling of Cytokines Sharing the Common γ Chain
Cytokine
Receptor IL-2R IL-4R IL-7R IL-9R IL-15R IL-21R
Functions Control of peripheral Regulation of B-cell Thymocyte survival Goblet cell CD8 memory T-cell T- and B-cell
self-tolerance (mice) function (in concert and development hyperplasia survival and proliferation
with interleukin factor proliferation factor factor
[IL]-21 and IL-25)
Development and Immunoglobulin Peripheral T-cell Mucus Peripheral T cell Regulates
maintenance of class switching survival factor production survival factor immunoglobulin
regulatory T cells Mediates homeostatic Mediates homeostatic production (with
reconstitution of reconstitution of IL-4)
lymphopenic animals lymphopenic animals
Differentiation of Differentiation of T B-cell progenitor Natural killer (NK) cell NK cell proliferation
helper and cytotoxic helper cells (Th2 survival factor (mice) development, and activation
T cells lineage) differentiation and factor
survival factor
In vitro expansion Costimulant for
and differentiation growth in T, B, and
of antigen-selected mast cells
T and NK cells
Inhibition of Th1
differentiation and
macrophage
activation
Downstream PI3K, Ras MAPK, PI3K, Ras MAPK, PI3K, STAT(1), (3), 5 PI3K, Ras MAPK, PI3K, Ras MAPK, PI3K, Ras MAPK,
signaling STAT1,3,5 STAT6,5 STAT1,3,(5) STAT1,3,5 STAT1,3,(5)
pathways