Page 202 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPTEr 11 Lymphocyte Adhesion and Trafficking 182.e1

MULTIPLE-CHOICE QUESTIONS

1. In the peripheral lymph nodes: C. Solely transmigrate through the endothelial cell cytoplasm
A. All lymphocytes enter the tissue through high endothelial by a transcytotic process
venules D. Mainly utilize selectins for the rolling step
B. Activated B lymphocytes exit the tissue by migrating to 3. Which one of the following therapies modulating lymphocyte
the subcapsular sinus and afferent lymphatics traffic is not currently used in clinics?
C. Chemokines immobilized on the high endothelial venules A. Functional antagonists of sphingosine 1 phosphate receptors
are crucial for triggering firm adhesion of bloodborne in reducing lymphocyte traffic to brain in multiple sclerosis
lymphocytes B. Agonists of L-selectin in enhancing lymphocyte homing
D. Effector T lymphocytes are imprinted to home selectively to spleen in sepsis
to gut
C. Function-blocking antibody against α in alleviating multiple
2. During the multistep adhesion, cascade lymphocytes: sclerosis
A. Use integrins mainly for tethering D. Function-blocking antibody against α 4 β 7 integrin in reduc-
B. Enter the spleen from the red pulp via capillary ing intestinal homing in inflammatory bowel disease
endothelium