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CHaPTEr 13 Regulated Necrosis and Its Immunogenicity 205

TABLE 13.1 Classification of Damage- 4. Zhao H, et al. Necroptosis and parthanatos are involved in remote lung
injury after receiving ischemic renal allografts in rats. Kidney Int
associated Molecular Patterns (DaMPs) 2015;87:738–48.
Class Definition Example(s) 5. Land WG, Agostinis P, Gasser S, et al. DAMP - Induced Allograft and
Tumor Rejection: The Circle is Closing. Am J Transplant
Ia Promoting DC maturation as sensed HMGB1 and 2016;16:3322–37.
by classical pattern recognition nucleic acids 6. Land WG, Agostinis P, Gasser S, et al. Transplantation and
receptors (e.g., TLR) Damage-Associated Molecular Patterns (DAMPs). Am J Transplant
Ib Promoting DC activation as recognized CALR and eATP 2016;16:3338–61.
by nonclassical pattern recognition 7. Rickard JA, et al. RIPK1 regulates RIPK3-MLKL-driven systemic
receptors (scavenger receptor CD91, inflammation and emergency hematopoiesis. Cell 2014;157:1175–88.
purinergic receptor P2X7)
II Second signal to NLRP3 Uric acid and eATP doi:10.1016/j.cell.2014.04.019.
inflammasome formation, giving rise 8. Schiering C, et al. The alarmin IL-33 promotes regulatory T-cell function
to monocyte activation in the intestine. Nature 2014;513:564–8.
III Assisting DC maturation as exposed MICs 9. Martinez J, et al. Noncanonical autophagy inhibits the autoinflammatory,
on stressed cells and sensed by lupus-like response to dying cells. Nature 2016;533:115–19. doi:10.1038/
NKG2D on natural killer cells nature17950.
IV Neoepitopes contributing to DC Oxidized 10. Hampe J, et al. A genome-wide association scan of nonsynonymous
activation, as they are recognized by phospholipids SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.
IgM antibodies, which activate the and actin Nat Genet 2007;39:207–11.
complement cascade cytoskeleton 11. Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, et al. Regulated
V Dyshomeostasis-associated molecular Accumulation of necrosis: the expanding network of non-apoptotic cell death pathways.
patterns sensed by NLRP3 receptor unfolded proteins Nat Rev Mol Cell Biol 2014;15:135–47.
or UPR receptors of stressed cells, in the ER, ion 12. Linkermann A, et al. Synchronized renal tubular cell death involves
thereby contributing to an perturbations and ferroptosis. Proc Natl Acad Sci USA 2014;111:16836–41. doi:10.1073/
inflammatory milieu redox stress pnas.1415518111.
13. Degterev A, Linkermann A. Generation of small molecules to interfere
an attempt to classify cell-death-associated damps.
DC, dendritic cell; HMGB1, high mobility group box-1; CALR, calreticulin; eATP, with regulated necrosis. Cell Mol Life Sci 2016;73:2251–67. doi:10.1007/
extracellular ATP; NK, natural killer; NKG2D, natural killer group 2 member D; MIC, s00018-016-2198-x.
MHC class I chain-related proteins; NLRP3, NOD-like receptor family, pyrin domain 14. Friedmann Angeli JP, et al. Inactivation of the ferroptosis regulator Gpx4
containing 3; ER, endoplasmic reticulum
triggers acute renal failure in mice. Nat Cell Biol 2014;16:1180–91.
doi:10.1038/ncb3064.
ACKNOWLEDGEMENTS 15. Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell
death. Cell 2012;149:1060–72.
This manuscript was supported by funding of the German 16. Yang WS, Stockwell BR. Ferroptosis: death by lipid peroxidation. Trends
Research Foundation, Cluster of Excellence 306 (EXC306) Cell Biol 2016;26:165–76. doi:10.1016/j.tcb.2015.10.014.
“Inflammation at Interfaces” to A.L. The authors acknowledge 17. Shimada K, Hayano M, Pagano NC, et al. Cell-Line Selectivity Improves
helpful discussions with Hans-Joachim Anders, Lorenzo Galluzzi, the Predictive Power of Pharmacogenomic Analyses and Helps Identify
NADPH as Biomarker for Ferroptosis Sensitivity. Cell Chem Biol
and Tom Vanden Berghe. 2016;23:225–35. doi:10.1016/j.chembiol.2015.11.016.
18. Tonnus W, Linkermann A. “Death is my Heir”–Ferroptosis Connects
Please check your eBook at https://expertconsult.inkling.com/ Cancer Pharmacogenomics and Ischemia-Reperfusion Injury. Cell Chem
for self-assessment questions. See inside cover for registration Biol 2016;23:202–3. doi:10.1016/j.chembiol.2016.02.005.
details. 19. Tait SW, et al. Widespread Mitochondrial Depletion via
Mitophagy Does Not Compromise Necroptosis. Cell Rep 2013;
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