Page 279 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHAPTER 17 Cytotoxic T Lymphocytes and Natural Killer Cells 259.e1

MULTIPLE-CHOICE QUESTIONS

1. How do cytotoxic T cells recognize target cells? 3. How do tumor cells evade cytotoxic T cells?
A. They cannot, only natural killer cells can recognize tumor A. Avoid them by residing away from the bloodstream
cells B. Express ligands that interact with inhibitory receptors on
B. Through detection via stress-induced ligands cytotoxic T cells
C. Recognition of major histocompatibility complex (MHC) C. Cytotoxic T cells cannot kill tumor cells
class I–peptide complexes specific for the T-cell receptor D. Proliferate more rapidly than the tumor cells
D. Through sensing the inflammatory environment
4. Natural killer cells selectively target:
2. How is the immunity provided by memory cells superior to A. The tumor microenvironment
that elicited by primary challenge? B. Immune cells activated by infection
A. The memory compartment has a higher frequency of cells C. Cells that have lost MHC class I expression on the cell
specific for the given antigen. surface
B. Memory cells are intrinsically able to respond faster to D. Memory cytotoxic T cells
rechallenge with the same infection.
C. Memory cells can remain at the site of previous 5. Which is NOT a pathway that cytotoxic T cells and natural
infection. killer cells use on their targets?
D. All of the above. A. Cellular senescence
B. Fas pathway
C. Perforin pores
D. Granzyme activity