Page 35 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPter 2 Organization of the Immune System 21

B-1 B cell IL-1, IL-13, Plasma cell
IL-5, IL-6
B cell Pre-B
progenitor cell IL-4 CD19, CD76 CD5, CD38, CD138
fit 3 Ligand IL-2 IL-10 CD20, CD23
B-2 B cell Plasma cell

IL-1, IL-4
CD19, CD79 IL-13, IL-5 CD38, CD138
CD20, CD23 IL-6
αβ T cell

Lymphoid T cell Pre-T CD3, CD4, CD8
progenitor progenitor cell γδ T cell
SCF IL-7 IL-7 IL-7, SCF

CD34, CD7, CD1 CD7, CD1 CD3, CD4, CD8
Pluripotential CD45RA, CD7 NK cell
hematopoietic
stem cell
IL-1, IL-3
IL-6, IL-11 IL-6 CD3, CD4, CD8
IL-12, SCF IL-7 NK cell Vα 24i
CD34 + SCF progenitor NK cell
or CD34 - fit 3 ligand
LIN - IL-15, 1L-12
IL-21
CD7, IL-15R CD16, CD56
Myeloid dendritic
cells CD83, CD80,
Platelet
Myeloid stem cell Megakaryocyte CD41, CD61, CD42 CD86 (DC1)
TPO, IL-11, IL-6
Plasmacytoid dendritic
cells CD303; IFNα (DC2)
CD31, CD49f CD42
CD34, CD33, GM-CSF, SCF CD41, CD61
HLA-DR
GM-CSF,TNF-α IL-4, TNF-α
GM-CSF, SCF, M-CSF, M-CSF, IL-3 IL-1, Promonocyte GM-CSF Monocyte GM-CSF Macrophage
IL-3, IL-1 IL-6, IL11, TPO M-CSF, IL-3 M-CSF
M-CSF, Monoblast CD41, CD35, CD64 CD68, CD35, CD64
IL-3 SCF GM-CSF,
M-CSF,
IL-3
CFU,
GEMM GM-CSF, CFU-GM GM-CSF, Myeloblast GM-CSF, Promyelocyte GM-CSF, Myelocyte GM-CSF, Metamyelocyte
IL-3 G-CSF G-CSF G-CSF G-CSF
CD34, CD33 CD34, CD33, CD34, CD33, CD33, CD13, CD15 CD33, CD13, CD33, CD13,
CD13, HLA-DR CD13, CD15 CD15, CD11b CD15, CD11b
GM-CSF, IL-3, CFU-Eo Eosinoophil GM-CSF IL-8
SCF
Bandform
CD9, CD16,
Basophil CD23, CD32
CD203c
BFU-E SCF, IL-3 CD33, CD13, CD15
CD16, CD11b
IL-4
Mast cell GM-CSF, G-CSF
IL-9 CD117 (c-Kit)
Neutrophil
GM-CSF, SCF, CFU-E Proerythroblast Erythrocyte
IL-3, EPO
TPO, EPO EPO
CD33, CD13, CD15
CD71, Glycophorin Glycophorin CD16, CD11b
Glycophorin
FIG 2.1 The differentiation of hematopoietic cells.