Page 30 - Clinical Immunology_ Principles and Practice ( PDFDrive )

16 Part one Principles of Immune Response

on tHe HorIZon 6. Tiburzy B, Kulkarni U, Hauser AE, et al. Plasma cells in
immunopathology: concepts and therapeutic strategies. Semin
enhancement of Immune responses Immunopathol 2014;36:277–88.
• Use of CRISPR/Cas9 technology in correction of gene defect in 7. Juelke K, Romagnani C. Differentiation of human innate lymphoid cells
monogenic immunodeficiency diseases (ILCs). Curr Opin Immunol 2016;38:75–85.
• Enhancement of molecular-pathway-specific cancer immunotherapy 8. Saunders PM, Vivian JP, O’Connor GM, et al. A bird’s eye view of NK cell
• Prediction of molecular targets and improvements in adjuvants for receptor interactions with their MHC class I ligands. Immunol Rev
vaccines 2015;267:148–66.
9. Liu H, Li L, Voss C, et al. A comprehensive immunoreceptor
Suppression of Immune responses phosphotyrosine-based signaling network revealed by reciprocal
• Further development of protocols for prevention of childhood allergic protein-peptide array screening. Mol Cell Proteomics 2015;14:1846–58.
diseases by appropriate environmental exposures in infancy 10. O’Sullivan TE, Sun JC, Lanier LL. Natural killer cell memory. Immunity
• Improved allergen-specific immunotherapy of allergic diseases 2015;43:634–45.
• Prevention of graft-versus-host disease in allogeneic bone marrow 11. Rezvani K, Rouce RH. The application of natural killer cell
transplantation cases immunotherapy for the treatment of cancer. Front Immunol 2015;6:578.
• Induction of antigen-specific immune tolerance in humans 12. Den Haan JM, Arens R, van Zelm MC. The activation of the adaptive
• Pharmacological development of specific inhibitors of cytokines, immune system: cross-talk between antigen-presenting cells, T cells and B
chemokines, and their receptors cells. Immunol Lett 2014;162:103–12.
13. Hammer GE, Ma A. Molecular control of steady-state dendritic cell
Immunodiagnostics and Immunopathogenesis maturation and immune homeostasis. Annu Rev Immunol
• Routine use of genomic analysis for development of personalized 2013;31:743–91.
medicine applicable to immunological diseases 14. Rossjohn J, Pellici DG, Patel O, et al. Recognition of CD1d-restricted
• Development of novel diagnostic tools based on nanotechnology arrays antigens by natural killer T cells. Nat Rev Immunol 2012;12:845–57.
• Application of gastrointestinal microbiome analysis in understanding 15. Hirano M, Das S, Guo P, et al. The evolution of adaptive immunity in
the pathogenesis of inflammatory bowel diseases, leading to novel vertebrates. Adv Immunol 2011;109:125–57.
therapeutic options 16. Xu Z, Jin B. A novel interface consisting of homologous immunoglobulin
• Understanding the role of inflammation in the pathogenesis of leading superfamily members with multiple functions. Cell Mol Immunol
causes of morbidity and mortality, including myocardial infarction, 2010;7:11–19.
stroke, and Alzheimer disease
17. Dudley DD, Chaudhuri J, Bassing CH, et al. Mechanism and control of
V(D)J recombination versus class switch recombination: similarities and
differences. Adv Immunol 2005;86:43–112.
immune system function and have contributed importantly to 18. Corcoran AE. Immunoglobulin locus silencing and allelic exclusion.
our appreciation of how aberrations of such functions are involved Semin Immunol 2005;17:141–54.
in the pathogenesis of disease. Insights gained from use of 19. Maul RW, Gearhart PJ. AID and somatic hypermutation. Adv Immunol
transgenic mice (including murine expression of human genes) 2010;105:159–91.
and constitutive or conditional gene-knockout mice are essential 20. Mechtcheriakova D, Svoboda M, Meshcheryakova A, et al.
to a comprehensive view of the immune system at the advancing Activation-induced cytidine deaminase (AID) linking immunity, chronic
edge of its clinical application, implying that future progress in inflammation, and cancer. Cancer Immunol Immunother
2012;61:1591–8.
clinical immunology will equally depend on detailed analysis in 21. von Boehmer H. Selection of the T-cell repertoire: receptor-controlled
such systems. It has become apparent, however, that there are checkpoints in T-cell development. Adv Immunol 2004;84:201–38.
important differences in aspects of the human and rodent immune 22. Coutinho A, Caramalho I, Seixas E, et al. Thymic commitment of
systems. Consequently, the carefully studied patient, particularly regulatory T cells is a pathway of TCR-dependent selection that isolates
when coupled with the power of increasingly feasible genome repertoires undergoing positive or negative selection. Curr Top Microbiol
and transcriptome sequencing, will remain the ultimate crucible Immunol 2005;293:43–71.
for understanding human immunity and the roles of the immune 23. Simons DM, Picca CC, Oh S, et al. How specificity for self-peptides
system in the pathogenesis of and protection from disease. shapes the development and function of regulatory T cells. J Leukoc Biol
2010;88:1099–107.
24. Hwang JK, Alt FW, Yeap LS. Related mechanisms of antibody somatic
Please check your eBook at https://expertconsult.inkling.com/ hypermutation and class switch recombination. Microbiol Spectr
for self-assessment questions. See inside cover for registration 2015;3:MDNA3-0037-2014.
details. 25. Madden DR. The three-dimensional structure of peptide-MHC
complexes. Annu Rev Immunol 1995;13:587–622.
REFERENCES 26. Hansen SG, Wu HL, Burwitz BJ, et al. Broadly targeted CD8 T cell
+
responses restricted by major histocompatibility complex E. Science
1. Flajnik MF, Kasahara M. Origin and evolution of the adaptive immune 2016;351:714–20.
system: genetic events and selective pressures. Nat Rev Genet 27. Mellins ED, Stern LJ. HLA-DM and HLA-DO, key regulators of MHC-II
2010;11:47–59. processing and presentation. Curr Opin Immunol 2014;26:115–22.
2. Buchmann K. Evolution of innate immunity: clues from invertebrates via 28. Cohen NR, Garg S, Brenner MB. Antigen presentation by CD1: lipids, T
fish to mammals. Front Immunol 2014;5:459. cells, and NKT cells in microbial immunity. Adv Immunol 2009;102:1–94.
3. Vivier E, Raulet DH, Moretta A, et al. Innate or adaptive immunity? The 29. Blum JS, Wearsch PA, Cresswell P. Pathways of antigen processing. Annu
example of natural killer cells. Science 2011;331:44–9. Rev Immunol 2013;31:443–73.
4. Liu J, Cao X. Cellular and molecular regulation in innate inflammatory 30. Godfrey DI, Uldrich AP, McCluskey J, et al. The burgeoning family of
responses. Cell Mol Immunol 2016;13:711–21. unconventional T cells. Nat Immunol 2015;16:1114–23.
5. Tukhvatulin AL, Dzharullaeva AS, Shcheblyakov DV, et al. Powerful 31. Spaulding AR, Salgado-Pabon W, Kohler PL, et al. Staphylococcal and
complex immunoadjuvant based on synergistic effect of combined TLR4 streptococcal superantigen exotoxins. Clin Microbiol Rev 2013;26:422–47.
and NOD2 activation significantly enhances magnitude of humoral and 32. Smith CW. Adhesion molecules and receptors. J Allergy Clin Immunol
cellular adaptive immune responses. PLoS ONE 2016;11:e0155650. 2008;121:S375–9.