Page 32 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPter 1 The Human Immune Response 17.e1

MUL t IPL e -CH o IC e QU e S t I on S

1. Which of the following statements regarding B cells is correct? 4. A 2-year-old child is referred for evaluation of massive
A. B cells can function as antigen-presenting cells (APCs). lymphadenopathy, splenomegaly, and apparent autoimmune
B. Activation for antibody production requires antigen anemia of 6 months’ duration without fever or weight loss.
presentation by APCs. You suspect the child’s primary problem is:
C. Activation requires association of B-cell receptors for A. Acute myelogenous leukemia
+
antigen with CD3. B. Excess production of IL-2 by CD4 T helper (Th) cells
D. Expression of major histocompatibility complex (MHC) C. Dysregulated proliferation of B cells
class II molecules on B cells requires cytokines produced D. Defective lymphocyte apoptosis
by APCs.
5. A 6-year-old boy is referred for evaluation of a presumptive
2. Natural killer (NK) cells of the innate immune system: diagnosis of a genetic deficiency of intercellular adhesion
A. Express clonally specific antigen receptors molecules. The referring pediatrician’s basis for this referral
B. Exhibit allelic exclusion of antigen receptors was:
C. Express receptors for immunoglobulin molecules A. Recurrent viral infections
D. Upregulate cytotoxic activity on virus-infected target cells B. Unusual susceptibility to infection with gram-negative
that express increased levels of major histocompatibility bacteria
complex (MHC) class I molecules C. Recurrent cutaneous abscesses
D. Presence of Pneumocystis jiroveci pneumonia
3. Expression of human leukocyte antigen (HLA) class I
molecules: 6. A 35-year old female presents with exophthalmos, tremor,
A. Exhibits allelic exclusion and weight loss. You suspect that the cause of her autoimmune
B. Is associated with activation-induced cytidine deaminase disease is:
C. Produces an antigen-binding site formed by folding of a A. Destruction of target gland hormone-producing cells
single polypeptide chain B. Destruction of target gland stromal cells
D. Comprises two polypeptide chains that are both encoded C. Blocking of target cell hormone receptors
within the HLA gene complex D. Stimulation of target cell hormone receptors