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CHaPtEr 24  Eosinophils and Eosinophilia           361.e1


              MUL t IPLE-CH o ICE QUES t I o NS

           1.  Which of the following may NOT contribute to or elicit   3.  Which three cytokines promote eosinophil development in
             eosinophilia?                                          bone marrow and sustain eosinophil viability?
                        +
                   −
              A. CD3 , CD4  aberrant lymphocyte subsets              A. Transforming growth factor (TGF)-β, interleukin (IL)-2,
              B. FIP1L1-PDGFRα chromosomal gene rearrangement          IL-4
              C. Giardia lamblia infection                           B. IL-7, IL-2, IL-13
              D. Strongyloides stercoralis infection                 C. Granulocyte macrophage–colony-stimulating factor (GM-
                                                                       CSF), IL-3, IL-5
           2.  A 45-year-old male who has had eosinophilia of between
                             3
             2500 and 5000/ mm  documented for the past 6 months has    D. Interferon (INF)-γ, IL-8, IL-10
             been referred to you. Your evaluation could include:
              A. Flow cytometry for lymphocyte phenotyping
              B. Serum immunoglobulin E (IgE)
              C. Serum troponin
              D. Strongyloides enzyme-linked immunosorbent assay (ELISA)
               serology
              E.  All of the above
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