Page 422 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHAPtER 27 Host Defenses to Extracellular Bacteria 402.e1

MUL t IPLE-CHOICE QUES t IONS

1. With regard to the use of corticosteroids as adjunctive therapy C. This patient should have diagnostic workup for terminal
for acute infections: complement deficiencies. Meningococcal vaccination should
A. Corticosteroids are immunosuppressive and should be be offered.
avoided during acute infections. D. This patient should have diagnostic workup for terminal
B. Corticosteroids are generally recommended for the treat- complement deficiencies. If confirmed, stem cell trans-
ment of sepsis. plantation can be offered.
C. Corticosteroids are never contraindicated during acute 3. The normal microbiota maintains a balance with the host
infections. by avoiding activation of pathogen recognition receptors.
D. Corticosteroids are beneficial in certain types of acute Pathogen recognition receptors are activated by pathogenic
infection, presumably because of their antiinflammatory bacteria only.
effect.
A. False. Colonizers and pathogens have pathogen-associated
2. A 18-year-old college freshman presents to the hospital with molecular patterns, and both can activate pattern recogni-
meningococcal meningitis. Upon review of his medical history, tion receptors.
you learn that he had disseminated gonococcal infection at B. True. Colonizers are devoid of pathogen-associated
the age of 16 years. Should you consider investigation for an molecular patterns.
immunodeficiency? If so, which one? Should you offer any C. True. Colonizers have pathogen-associated molecular
prophylactic therapies for this patient? patterns but do not activate pathogen recognition
A. No investigation for an immunodeficiency is warranted. receptors.
Meningococcal vaccination should be offered. D. False. Colonizers and pathogens have pathogen-associated
B. These infections suggest a T-helper (Th)17 deficiency, molecular patterns, and both can activate pattern recogni-
and there is no approved prophylactic therapy for this tion receptors, but colonizers only do so when invading
disorder. host tissues.