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CHaPter 2 Organization of the Immune System 37

Stratum corneum Stratum corneum

Epidermis
Epidermis
Langerhans cells
Dermis

Dermis

Blood vessels / Lymphatics

Blood
vessel

Lymphatics
A C

B D
FIG 2.12 Lymphoid Regions in Human Skin. (A, C) Organization of the epithelial tissue. (B)
Epithelial tissue stained with hematoxylin and eosin. (D) Epithelial tissue stained with anti-CD207
to demonstrate the distribution of Langerhans cells (note brown cells).

REFERENCES learned and possible clinical applications. Exp Hematol 2014;41:
411–23.
1. Rampon C, Huber P. Multilineage hematopoietic progenitor activity 3. Smith JNP, Calvi LM. Current concepts in bone marrow
generated autonomously in the mouse yolk sac: analysis using microenvironmental regulation of hematopoietic stem and progenitor
angiogenesis-defective embryos. Int J Dev Biol 2003;47:273–80. cells. Stem Cells 2013;6:1044–50.
2. Ciriza J, Thompson H, Petrosian R, et al. The migration of hematopoietic 4. Copley MR, Eaves CJ. Developmental changes in hematopoietic stem cell
progenitors from the fetal liver to the fetal bone marrow: lessons properties. Exp Mol Med 2013;45:e55.