Page 557 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPtEr 37 Infections in the Immunocompromised Host 534.e1

M u L t IPLE CH o ICE Q u ES t I o NS

1. Mucocutaneous candidiasis is thought to occur due to disrup- 3. Progressive multifocal leukoencephalopathy has been described
tion of interleukin-17 (IL-17) signaling. This is observed in in the following settings EXCEPT:
all of the following immunodeficiencies EXCEPT: A. Rituximab
A. Loss of function mutations in signal transducer and activa- B. GOF STAT1 mutations
tor of transcription 3 (STAT3) causing hyper IgE syndrome C. Natalizumab
(HIES) D. Chronic granulomatous disease (CGD)
B. CD40 ligand deficiency E. Human immunodeficiency virus (HIV)
C. Gain-of-function (GOF) STAT1 mutations F. Dedicator of cytokinesis 8 (DOCK8) deficiency
D. Autoimmune polyendocrinopathy with candidiasis and 4. Photosensitivity is associated with which antifungal?
ectodermal dysplasia (APOCED)
A. Fluconazole
2. Anticytokine autoantibodies are increasingly being recognized B. Caspofungin
as causing immunodeficiency. The following are described C. Posaconazole
associations EXCEPT: D. Voriconazole
A. Anti-interferon (IFN)-γ antibodies and disseminated E. Isavuconazole
nontuberculous mycobacteria
B. Anti–GM-CSF antibodies and Cryptococcus
C. Anti-IL-17 antibodies and mucocutaneous Candida
D. Anti-IFNγ antibodies and Staphylococcus aureus
E. Anti–granulocyte macrophage–colony-stimulating factor
(GM-CSF) antibodies and Nocardia