Page 387 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

PA RT S IX

Neoplastic Disorders

20 Characteristics of Leukemias,

Principles of Blood Collection
CHAPTER Lymphomas, and Myelomas

KEY TERMS

acute lym phadenopathy tum or-suppressing genes
aneuploidy lym phom as vaccine
chronic myelomas World Health Organization (WHO)

French-Am erican-British (FAB) neoplasm s classi cation

classi cation oncogenes
leukem ia protooncogenes

LEARNING OUTCOMES

Comparison of leukemias, lymphomas, and ■ Name one genetic defect that is correlated with an increased inci-

myelomas dence of leukemia.

■ De ne and differentiate the terms neoplasm and malignant. ■ Explain the signi cance of the discovery of the human T-cell leuke-

■ Compare the characteristics of leukemia, lymphoma, and myeloma. mia virus (HTLV) family and describe associated disorders.
■ Describe the role of protooncogenes and oncogenes in leukemias
Forms of leukemia and lymphomas.

■ De ne and compare the terms acute and chronic leukemia. Demographic distribution of leukemia and

■ Differentiate between acute and chronic myeloid and lymphoid leu-

kemias based on clinical and hematologic ndings. lymphomas

■ Describe the variations in the incidence of leukemia in different eth-
Classi cations of leukemias nic and racial groups.

■ List the traditional forms of the major types of leukemias. ■ Correlate patient age to the overall incidence of various leukemias

■ Compare the FAB and WHO staging systems for leukemias. (hematopoietic neoplasms).

■ Describe the overall differences between the incidences of leuke-
Prognosis and treatment mia in female and male patients.

■ Compare the early treatment of leukemias and lymphomas with cur-
rent therapy. Leukemia vaccines

■ Explain the role of vaccines in treatment and/or prevention of
Factors related to the occurrence of leukemia leukemias.

Describe the effects of ionizing radiation on the incidence of

leukemia.

Name one chemical that is correlated with an increased incidence NOTE:

of leukemia. indicates MLT and MLS core content

Name several occupations that are associated with a higher-than- ■
indicates MLT (optional) and MLS advanced content
normal risk of hematological malignancies.

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